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TargetGlutaminase kidney isoform, mitochondrial
LigandBDBM108852
Substrate/Competitorn/a
Meas. Tech.Enzyme Assay-Time Dependence
IC50 2± 0 nM
Citation Li JChen LGoyal BLaidig GStanton TFSjogren EB Heterocyclic inhibitors of glutaminase US Patent  US8604016 Publication Date 12/10/2013
More Info.:Get all data from this article,  Assay Method
 
Glutaminase kidney isoform, mitochondrial
Name:Glutaminase kidney isoform, mitochondrial
Synonyms:GLS | GLS1 | Glutaminase 1 | K-glutaminase | KIAA0838 | L-glutamine amidohydrolase
Type:Protein
Mol. Mass.:73471.89
Organism:Homo sapiens (Human)
Description:O94925
Residue:669
Sequence:
MMRLRGSGMLRDLLLRSPAGVSATLRRAQPLVTLCRRPRGGGRPAAGPAAAARLHPWWGG
GGWPAEPLARGLSSSPSEILQELGKGSTHPQPGVSPPAAPAAPGPKDGPGETDAFGNSEG
KELVASGENKIKQGLLPSLEDLLFYTIAEGQEKIPVHKFITALKSTGLRTSDPRLKECMD
MLRLTLQTTSDGVMLDKDLFKKCVQSNIVLLTQAFRRKFVIPDFMSFTSHIDELYESAKK
QSGGKVADYIPQLAKFSPDLWGVSVCTVDGQRHSTGDTKVPFCLQSCVKPLKYAIAVNDL
GTEYVHRYVGKEPSGLRFNKLFLNEDDKPHNPMVNAGAIVVTSLIKQGVNNAEKFDYVMQ
FLNKMAGNEYVGFSNATFQSERESGDRNFAIGYYLKEKKCFPEGTDMVGILDFYFQLCSI
EVTCESASVMAATLANGGFCPITGERVLSPEAVRNTLSLMHSCGMYDFSGQFAFHVGLPA
KSGVAGGILLVVPNVMGMMCWSPPLDKMGNSVKGIHFCHDLVSLCNFHNYDNLRHFAKKL
DPRREGGDQRVKSVINLLFAAYTGDVSALRRFALSAMDMEQRDYDSRTALHVAAAEGHVE
VVKFLLEACKVNPFPKDRWNNTPMDEALHFGHHDVFKILQEYQVQYTPQGDSDNGKENQT
VHKNLDGLL
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  Blast E-value cutoff:
BDBM108852
n/a
NameBDBM108852
Synonyms:US8604016, 432
TypeSmall organic molecule
Emp. Form.C34H33N7O3S
Mol. Mass.619.736
SMILESO=C(Cc1cccc(CNC(=O)c2ccccc2)c1)Nc1nnc(CCCCc2ccc(NC(=O)Cc3ccccc3)nn2)s1
Structure
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