| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Cathepsin B |
|---|
| Ligand | BDBM109862 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Enzyme Inhibition Assay |
|---|
| Ki | 46±0.0 nM |
|---|
| Citation |  Schudok, M; Wagner, M; Bauer, A; Kohlmann, A Spirocyclic nitriles as protease inhibitors US Patent US8609681 Publication Date 12/17/2013 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Cathepsin B |
|---|
| Name: | Cathepsin B |
|---|
| Synonyms: | APP secretase | APPS | CATB_HUMAN | CPSB | CTSB | Cathepsin B heavy chain | Cathepsin B light chain | Cathepsin B1 |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 37819.69 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | gi_63102437 |
|---|
| Residue: | 339 |
|---|
| Sequence: | MWQLWASLCCLLVLANARSRPSFHPLSDELVNYVNKRNTTWQAGHNFYNVDMSYLKRLCG
TFLGGPKPPQRVMFTEDLKLPASFDAREQWPQCPTIKEIRDQGSCGSCWAFGAVEAISDR
ICIHTNAHVSVEVSAEDLLTCCGSMCGDGCNGGYPAEAWNFWTRKGLVSGGLYESHVGCR
PYSIPPCEHHVNGSRPPCTGEGDTPKCSKICEPGYSPTYKQDKHYGYNSYSVSNSEKDIM
AEIYKNGPVEGAFSVYSDFLLYKSGVYQHVTGEMMGGHAIRILGWGVENGTPYWLVANSW
NTDWGDNGFFKILRGQDHCGIESEVVAGIPRTDQYWEKI
|
|
|
|---|
| BDBM109862 |
|---|
| n/a |
|---|
| Name | BDBM109862 |
|---|
| Synonyms: | US8609681, 9 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C20H30F2N4O2 |
|---|
| Mol. Mass. | 396.4746 |
|---|
| SMILES | CC(F)(F)C[C@H](NC(=O)N1CCC2(CCCCC2)CC1)C(=O)NC1(CC1)C#N |
|---|
| Structure | 
|
|---|
Search and Browse
