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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Tyrosine-protein kinase JAK1 | ||
| Ligand | BDBM113144 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Enzymatic Assay | ||
| pH | 7.4±n/a | ||
| IC50 | 2.4±n/a nM | ||
| Comments | extracted | ||
| Citation |  Promo, MA; Xie, J; Acker, BA; Hartmann, SJ; Wolfson, SG; Huang, H; Jacobsen, EJ Pyrrolo[2,3-D]pyrimidine compounds US Patent US8633206 Publication Date 1/21/2014 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Tyrosine-protein kinase JAK1 | |||
| Name: | Tyrosine-protein kinase JAK1 | ||
| Synonyms: | JAK-1 | JAK1 | JAK1A | JAK1B | JAK1_HUMAN | Janus kinase 1 | Janus kinase 1 (JAK1) | Janus kinase 1 JAK1 | ||
| Type: | Protein | ||
| Mol. Mass.: | 133293.73 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P23458 | ||
| Residue: | 1154 | ||
| Sequence: |
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| BDBM113144 | |||
| n/a | |||
| Name | BDBM113144 | ||
| Synonyms: | US8633206, 62 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C20H31N5O3S | ||
| Mol. Mass. | 421.557 | ||
| SMILES | CN([C@H]1CC[C@H](CS(=O)(=O)N2CCC[C@H](CO)C2)CC1)c1ncnc2[nH]ccc12 |r,wU:5.5,14.14,wD:2.1,(5.48,.38,;4.15,-.38,;2.82,.38,;2.82,1.93,;1.48,2.69,;.15,1.93,;-1.18,2.69,;-2.52,1.93,;-2.52,.38,;-1.18,1.15,;-3.85,2.69,;-3.85,4.23,;-5.19,5,;-6.52,4.23,;-6.52,2.69,;-7.85,1.93,;-7.85,.39,;-5.19,1.93,;.15,.38,;1.48,-.38,;4.15,-1.93,;2.82,-2.69,;2.82,-4.23,;4.15,-5,;5.48,-4.23,;6.95,-4.71,;7.85,-3.47,;6.95,-2.22,;5.48,-2.69,)| | ||
| Structure | 
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