| Reaction Details |
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 | Report a problem with these data |
| Target | Histone deacetylase 2 |
|---|
| Ligand | BDBM249366 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | HDAC Enzyme Assay |
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| pH | 7.4±n/a |
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| Temperature | 298.15±n/a K |
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| IC50 | 982±n/a nM |
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| Comments | extracted |
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| Citation |  Mazitschek, R; van Duzer, JH Pyrimidine hydroxy amide compounds as HDAC6 selective inhibitors US Patent US9884850 Publication Date 2/6/2018 |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Histone deacetylase 2 |
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| Name: | Histone deacetylase 2 |
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| Synonyms: | Cereblon/Histone deacetylase 2 | HD2 | HDAC2 | HDAC2_HUMAN | Histone deacetylase 2 (HDAC2) | Human HDAC2 |
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| Type: | Chromatin regulator; hydrolase; repressor |
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| Mol. Mass.: | 55356.54 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q92769 |
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| Residue: | 488 |
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| Sequence: | MAYSQGGGKKKVCYYYDGDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKA
TAEEMTKYHSDEYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVA
GAVKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHH
GDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNFPMRDGIDDESYGQ
IFKPIISKVMEMYQPSAVVLQCGADSLSGDRLGCFNLTVKGHAKCVEVVKTFNLPLLMLG
GGGYTIRNVARCWTYETAVALDCEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTPEYM
EKIKQRLFENLRMLPHAPGVQMQAIPEDAVHEDSGDEDGEDPDKRISIRASDKRIACDEE
FSDSEDEGEGGRRNVADHKKGAKKARIEEDKKETEDKKTDVKEEDKSKDNSGEKTDTKGT
KSEQLSNP
|
|
|
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| BDBM249366 |
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| n/a |
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| Name | BDBM249366 |
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| Synonyms: | US9464073, 003 | US9884850, Compound 3 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H18F2N4O2 |
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| Mol. Mass. | 348.3472 |
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| SMILES | ONC(=O)c1cnc(NC2(CCC(F)(F)CC2)c2ccccc2)nc1 |
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| Structure | 
|
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