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TargetPvdQ
LigandBDBM113799
Substrate/Competitorn/a
Meas. Tech.PvdQ IC50 Assay
IC50 1e+1± 1 nM
Citation Wurst JMDrake EJTheriault JRJewett ITVerPlank LPerez JRDandapani SPalmer MMoskowitz SMSchreiber SLMunoz BGulick AM Identification of Inhibitors of PvdQ, an Enzyme Involved in the Synthesis of the Siderophore Pyoverdine. ACS Chem Biol 9:1536-44 (2014) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
PvdQ
Name:PvdQ
Synonyms:n/a
Type:Protein
Mol. Mass.:84038.62
Organism:Pseudomonas aeruginosa
Description:Ntn hydrolase
Residue:762
Sequence:
MGMRTVLTGLAGMLLGSMMPVQADMPRPTGLAADIRWTAYGVPHIRAKDERGLGYGIGYA
YARDNACLLAEEIVTARGERARYFGSEGKSSAELDNLPSDIFYAWLNQPEALQAFWQAQT
PAVRQLLEGYAAGFNRFLREADGKTTSCLGQPWLRAIATDDLLRLTRRLLVEGGVGQFAD
ALVAAAPPGTEKVALSGEQAFQVAEQRRQRFRLERGSNAIAVGSERSADGKGMLLANPHF
PWNGAMRFYQMHLTIPGRLDVMGASLPGLPVVNIGFSRHLAWTHTVDTSSHFTLYRLALD
PKDPRRYLVDGRSLPLEEKSVAIEVRGADGKLSRVEHKVYQSIYGPLVVWPGKLDWNRSE
AYALRDANLENTRVLQQWYSINQASDVADLRRRVEALQGIPWVNTLAADEQGNALYMNQS
VVPYLKPELIPACAIPQLVAEGLPALQGQDSRCAWSRDPAAAQAGITPAAQLPVLLRRDF
VQNSNDSAWLTNPASPLQGFSPLVSQEKPIGPRARYALSRLQGKQPLEAKTLEEMVTANH
VFSADQVLPDLLRLCRDNQGEKSLARACAALAQWDRGANLDSGSGFVYFQRFMQRFAELD
GAWKEPFDAQRPLDTPQGIALDRPQVATQVRQALADAAAEVEKSGIPDGARWGDLQVSTR
GQERIAIPGGDGHLGVYNAIQSVRKGDHLEVVGGTSYIQLVTFPEEGPKARGLLAFSQSS
DPRSPHYRDQTELFSRQQWQTLPFSDRQIDADPQLQRLSIRE
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM113799
n/a
NameBDBM113799
Synonyms:2-(4-Chloro-2-fluorophenyl)-2-(5-(trifluoromethyl)-pyridin-2-yl)acetonitrile (31)
TypeSmall organic molecule
Emp. Form.C14H7ClF4N2
Mol. Mass.314.665
SMILESFc1cc(Cl)ccc1C(C#N)c1ccc(cn1)C(F)(F)F
Structure
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