| Reaction Details |
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 | Report a problem with these data |
| Target | Disintegrin and metalloproteinase domain-containing protein 17 |
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| Ligand | BDBM113939 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Counterscreen for exosite inhibitors of ADAM10: QFRET-based biochemical high throughput dose response assay to identify inhibitors of ADAM17 |
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| IC50 | 69502±n/a nM |
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| Citation |  PubChem, PC Counterscreen for exosite inhibitors of ADAM10: QFRET-based biochemical high throughput dose response assay to identify inhibitors of ADAM17 PubChem Bioassay(2014)[AID] |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Disintegrin and metalloproteinase domain-containing protein 17 |
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| Name: | Disintegrin and metalloproteinase domain-containing protein 17 |
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| Synonyms: | ADA17_HUMAN | ADAM17 | CSVP | Disintegrin and metalloproteinase domain-containing protein 17 (ADAM-17) | Disintegrin and metalloproteinase domain-containing protein 17 (ADAM17) | TACE | TNF-alpha convertase | TNF-alpha converting enzyme (TACE) | TNF-alpha-converting enzyme (TACE) | Tumor Necrosis Factor Alpha Converting Enzyme | Tumor necrosis factor-α converting enzyme (TACE) |
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| Type: | Enzyme |
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| Mol. Mass.: | 93007.89 |
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| Organism: | Homo sapiens (Human) |
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| Description: | |
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| Residue: | 824 |
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| Sequence: | MRQSLLFLTSVVPFVLAPRPPDDPGFGPHQRLEKLDSLLSDYDILSLSNIQQHSVRKRDL
QTSTHVETLLTFSALKRHFKLYLTSSTERFSQNFKVVVVDGKNESEYTVKWQDFFTGHVV
GEPDSRVLAHIRDDDVIIRINTDGAEYNIEPLWRFVNDTKDKRMLVYKSEDIKNVSRLQS
PKVCGYLKVDNEELLPKGLVDREPPEELVHRVKRRADPDPMKNTCKLLVVADHRFYRYMG
RGEESTTTNYLIELIDRVDDIYRNTSWDNAGFKGYGIQIEQIRILKSPQEVKPGEKHYNM
AKSYPNEEKDAWDVKMLLEQFSFDIAEEASKVCLAHLFTYQDFDMGTLGLAYVGSPRANS
HGGVCPKAYYSPVGKKNIYLNSGLTSTKNYGKTILTKEADLVTTHELGHNFGAEHDPDGL
AECAPNEDQGGKYVMYPIAVSGDHENNKMFSNCSKQSIYKTIESKAQECFQERSNKVCGN
SRVDEGEECDPGIMYLNNDTCCNSDCTLKEGVQCSDRNSPCCKNCQFETAQKKCQEAINA
TCKGVSYCTGNSSECPPPGNAEDDTVCLDLGKCKDGKCIPFCEREQQLESCACNETDNSC
KVCCRDLSGRCVPYVDAEQKNLFLRKGKPCTVGFCDMNGKCEKRVQDVIERFWDFIDQLS
INTFGKFLADNIVGSVLVFSLIFWIPFSILVHCVDKKLDKQYESLSLFHPSNVEMLSSMD
SASVRIIKPFPAPQTPGRLQPAPVIPSAPAAPKLDHQRMDTIQEDPSTDSHMDEDGFEKD
PFPNSSTAAKSFEDLTDHPVTRSEKAASFKLQRQNRVDSKETEC
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| BDBM113939 |
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| n/a |
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| Name | BDBM113939 |
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| Synonyms: | 2-[(4-bromo-2-methyl-phenyl)thio]acetic acid [2-[4-(diethylamino)anilino]-2-keto-ethyl] ester;sulfuric acid | 2-[(4-bromo-2-methylphenyl)thio]acetic acid [2-[4-(diethylamino)anilino]-2-oxoethyl] ester;sulfuric acid | MLS002635793 | SMR000263687 | [2-[4-(diethylamino)anilino]-2-oxoethyl] 2-(4-bromo-2-methylphenyl)sulfanylacetate;sulfuric acid | [2-[[4-(diethylamino)phenyl]amino]-2-oxidanylidene-ethyl] 2-(4-bromanyl-2-methyl-phenyl)sulfanylethanoate;sulfuric acid | cid_12006230 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H25BrN2O3S |
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| Mol. Mass. | 465.404 |
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| SMILES | CCN(CC)c1ccc(NC(=O)COC(=O)CSc2ccc(Br)cc2C)cc1 |
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| Structure | 
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