BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetTyrosyl-DNA phosphodiesterase 2
LigandBDBM70782
Substrate/Competitorn/a
Meas. Tech.Epi Absorbance-based biochemical high throughput dose response assay to identify inhibitors of human tyrosyl-DNA phosphodiesterase 2 (TDP2)
IC50 3297±n/a nM
Citation PubChem, PC Epi Absorbance-based biochemical high throughput dose response assay to identify inhibitors of human tyrosyl-DNA phosphodiesterase 2 (TDP2) PubChem Bioassay(2014)[AID]
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Tyrosyl-DNA phosphodiesterase 2
Name:Tyrosyl-DNA phosphodiesterase 2
Synonyms:EAP2 | EAPII | ETS1-associated protein 2 | ETS1-associated protein II | TDP2 | TRAF and TNF receptor-associated protein | TTRAP | TYDP2_HUMAN | Tyr-DNA phosphodiesterase 2 | Tyrosyl-DNA phosphodiesterase 2 | Tyrosyl-DNA phosphodiesterase 2 (hTDP2) | Tyrosyl-RNA phosphodiesterase | VPg unlinkase | hTDP2
Type:Enzyme Catalytic Domain
Mol. Mass.:40916.54
Organism:Homo sapiens (Human)
Description:gi_23510348
Residue:362
Sequence:
MELGSCLEGGREAAEEEGEPEVKKRRLLCVEFASVASCDAAVAQCFLAENDWEMERALNS
YFEPPVEESALERRPETISEPKTYVDLTNEETTDSTTSKISPSEDTQQENGSMFSLITWN
IDGLDLNNLSERARGVCSYLALYSPDVIFLQEVIPPYYSYLKKRSSNYEIITGHEEGYFT
AIMLKKSRVKLKSQEIIPFPSTKMMRNLLCVHVNVSGNELCLMTSHLESTRGHAAERMNQ
LKMVLKKMQEAPESATVIFAGDTNLRDREVTRCGGLPNNIVDVWEFLGKPKHCQYTWDTQ
MNSNLGITAACKLRFDRIFFRAAAEEGHIIPRSLDLLGLEKLDCGRFPSDHWGLLCNLDI
IL
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM70782
n/a
NameBDBM70782
Synonyms:(NZ)-N-[4-keto-3-(p-toluidino)-1-naphthylidene]thiophene-2-sulfonamide | MLS000585839 | N-[(1Z)-3-[(4-methylphenyl)amino]-4-oxonaphthalen-1(4H)-ylidene]thiophene-2-sulfonamide | N-[3-(4-methylanilino)-4-oxo-1-naphthalenylidene]-2-thiophenesulfonamide | N-[3-(4-methylanilino)-4-oxonaphthalen-1-ylidene]thiophene-2-sulfonamide | N-[3-[(4-methylphenyl)amino]-4-oxidanylidene-naphthalen-1-ylidene]thiophene-2-sulfonamide | N-[4-keto-3-(p-toluidino)-1-naphthylidene]thiophene-2-sulfonamide | SMR000207620 | cid_4192573
TypeSmall organic molecule
Emp. Form.C21H16N2O3S2
Mol. Mass.408.493
SMILESCc1ccc(NC2=CC(=NS(=O)(=O)c3cccs3)c3ccccc3C2=O)cc1 |w:9.9,t:6|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: