| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Major prion protein |
|---|
| Ligand | BDBM114429 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | TRFRET-based cell-based high throughput dose response assay to identify inhibitors of cell surface Prion Protein (PRPC) |
|---|
| IC50 | 1980±n/a nM |
|---|
| Citation |  PubChem, PC TRFRET-based cell-based high throughput dose response assay to identify inhibitors of cell surface Prion Protein (PRPC) PubChem Bioassay(2014)[AID] |
|---|
| More Info.: | Get all data from this article, Solution Info, Assay Method |
|---|
| |
| Major prion protein |
|---|
| Name: | Major prion protein |
|---|
| Synonyms: | ALTPRP | ASCR | CD_antigen=CD230 | PRIO_HUMAN | PRIP | PRNP | PRP | PrP27-30 | PrP33-35C | Prion protein | major prion protein preproprotein |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 27671.97 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_158887 |
|---|
| Residue: | 253 |
|---|
| Sequence: | MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQP
HGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGA
VVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCV
NITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPV
ILLISFLIFLIVG
|
|
|
|---|
| BDBM114429 |
|---|
| n/a |
|---|
| Name | BDBM114429 |
|---|
| Synonyms: | 4-Methoxy-benzoic acid N'-[2-(2-isopropyl-quinazolin-4-ylsulfanyl)-acetyl]-hydrazide | 4-methoxy-N'-[1-oxo-2-[(2-propan-2-yl-4-quinazolinyl)thio]ethyl]benzohydrazide | 4-methoxy-N'-[2-(2-propan-2-ylquinazolin-4-yl)sulfanylacetyl]benzohydrazide | 4-methoxy-N'-[2-(2-propan-2-ylquinazolin-4-yl)sulfanylethanoyl]benzohydrazide | MLS001221823 | N'-[2-[(2-isopropylquinazolin-4-yl)thio]acetyl]-4-methoxy-benzohydrazide | SMR000607289 | cid_24793479 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C21H22N4O3S |
|---|
| Mol. Mass. | 410.489 |
|---|
| SMILES | COc1ccc(cc1)C(=O)NNC(=O)CSc1nc(nc2ccccc12)C(C)C |
|---|
| Structure | 
|
|---|
Search and Browse
