| Reaction Details |
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 | Report a problem with these data |
| Target | Methyl-CpG-binding domain protein 2 |
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| Ligand | BDBM79511 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | TRFRET-based biochemical high throughput dose response assay to identify inhibitors of 5-meCpG-binding domain protein 2 (MBD2)-DBD binding to methylated oligonucleotide |
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| IC50 | 4409±n/a nM |
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| Citation |  PubChem, PC TRFRET-based biochemical high throughput dose response assay to identify inhibitors of 5-meCpG-binding domain protein 2 (MBD2)-DBD binding to methylated oligonucleotide PubChem Bioassay(2013)[AID] |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Methyl-CpG-binding domain protein 2 |
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| Name: | Methyl-CpG-binding domain protein 2 |
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| Synonyms: | MBD2 | MBD2_HUMAN | Methyl-CpG binding domain protein 2 | Methyl-CpG-binding domain protein 2 (MBD2) |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 43278.74 |
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| Organism: | Homo sapiens (Human) |
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| Description: | gi_21595776 |
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| Residue: | 411 |
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| Sequence: | MRAHPGGGRCCPEQEEGESAAGGSGAGGDSAIEQGGQGSALAPSPVSGVRREGARGGGRG
RGRWKQAGRGGGVCGRGRGRGRGRGRGRGRGRGRGRPPSGGSGLGGDGGGCGGGGSGGGG
APRREPVPFPSGSAGPGPRGPRATESGKRMDCPALPPGWKKEEVIRKSGLSAGKSDVYYF
SPSGKKFRSKPQLARYLGNTVDLSSFDFRTGKMMPSKLQKNKQRLRNDPLNQNKGKPDLN
TTLPIRQTASIFKQPVTKVTNHPSNKVKSDPQRMNEQPRQLFWEKRLQGLSASDVTEQII
KTMELPKGLQGVGPGSNDETLLSAVASALHTSSAPITGQVSAAVEKNPAVWLNTSQPLCK
AFIVTDEDIRKQEERVQQVRKKLEEALMADILSRAADTEEMDIEMDSGDEA
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| BDBM79511 |
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| n/a |
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| Name | BDBM79511 |
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| Synonyms: | MLS001116571 | N-(2-chlorobenzyl)-3-[(3-keto-4H-1,4-benzothiazin-6-yl)sulfonyl]-2-methyl-propionamide | N-[(2-chlorophenyl)methyl]-2-methyl-3-[(3-oxidanylidene-4H-1,4-benzothiazin-6-yl)sulfonyl]propanamide | N-[(2-chlorophenyl)methyl]-2-methyl-3-[(3-oxo-4H-1,4-benzothiazin-6-yl)sulfonyl]propanamide | SMR000630020 | cid_20923253 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H19ClN2O4S2 |
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| Mol. Mass. | 438.948 |
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| SMILES | CC(CS(=O)(=O)c1ccc2SCC(=O)Nc2c1)C(=O)NCc1ccccc1Cl |
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| Structure | 
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