Ki Summary

Reaction Details

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Target

Methyl-CpG-binding domain protein 2

Ligand

BDBM114651

Substrate/Competitor

n/a

Meas. Tech.

TRFRET-based biochemical high throughput dose response assay to identify inhibitors of 5-meCpG-binding domain protein 2 (MBD2)-DBD binding to methylated oligonucleotide

IC50

9588±n/a nM

Citation

PubChem, PC TRFRET-based biochemical high throughput dose response assay to identify inhibitors of 5-meCpG-binding domain protein 2 (MBD2)-DBD binding to methylated oligonucleotide PubChem Bioassay(2013)[AID]

More Info.:

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Methyl-CpG-binding domain protein 2

Name:

Methyl-CpG-binding domain protein 2

Synonyms:

MBD2 | MBD2_HUMAN | Methyl-CpG binding domain protein 2 | Methyl-CpG-binding domain protein 2 (MBD2)

Type:

Enzyme Catalytic Domain

Mol. Mass.:

43278.74

Organism:

Homo sapiens (Human)

Description:

gi_21595776

Residue:

411

Sequence:

MRAHPGGGRCCPEQEEGESAAGGSGAGGDSAIEQGGQGSALAPSPVSGVRREGARGGGRG
RGRWKQAGRGGGVCGRGRGRGRGRGRGRGRGRGRGRPPSGGSGLGGDGGGCGGGGSGGGG
APRREPVPFPSGSAGPGPRGPRATESGKRMDCPALPPGWKKEEVIRKSGLSAGKSDVYYF
SPSGKKFRSKPQLARYLGNTVDLSSFDFRTGKMMPSKLQKNKQRLRNDPLNQNKGKPDLN
TTLPIRQTASIFKQPVTKVTNHPSNKVKSDPQRMNEQPRQLFWEKRLQGLSASDVTEQII
KTMELPKGLQGVGPGSNDETLLSAVASALHTSSAPITGQVSAAVEKNPAVWLNTSQPLCK
AFIVTDEDIRKQEERVQQVRKKLEEALMADILSRAADTEEMDIEMDSGDEA

BDBM114651

n/a

Name

BDBM114651

Synonyms:

CHEMBL1716096 | MLS002607798 | N-[3-(1,3-benzothiazol-2-yl)-6-isopropyl-4,5,7,8-tetrahydrothien[2,3-d]azepin-2-yl]acetamide;2,2,2-trifluoroacetic acid | N-[3-(1,3-benzothiazol-2-yl)-6-propan-2-yl-4,5,7,8-tetrahydrothieno[2,3-d]azepin-2-yl]acetamide;2,2,2-trifluoroacetic acid | N-[3-(1,3-benzothiazol-2-yl)-6-propan-2-yl-4,5,7,8-tetrahydrothieno[2,3-d]azepin-2-yl]ethanamide;2,2,2-tris(fluoranyl)ethanoic acid | SMR001522672 | cid_53338857

Type

Small organic molecule

Emp. Form.

C20H23N3OS2

Mol. Mass.

385.546

SMILES

CC(C)N1CCc2sc(NC(C)=O)c(-c3nc4ccccc4s3)c2CC1

Structure