| Reaction Details |
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 | Report a problem with these data |
| Target | Protein artemis |
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| Ligand | BDBM32262 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Dose Response confirmation of small molecule inhibitors originally identified via uHTS of Artemis endonuclease activity via a fluorescence intensity assay |
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| IC50 | 19800±n/a nM |
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| Citation |  PubChem, PC Dose Response confirmation of small molecule inhibitors originally identified via uHTS of Artemis endonuclease activity via a fluorescence intensity assay PubChem Bioassay(2013)[AID] |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Protein artemis |
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| Name: | Protein artemis |
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| Synonyms: | ARTEMIS | ASCID | DCLRE1C | DCR1C_HUMAN | SCIDA | SNM1C | protein artemis isoform a |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 78427.91 |
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| Organism: | Homo sapiens (Human) |
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| Description: | gi_76496497 |
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| Residue: | 692 |
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| Sequence: | MSSFEGQMAEYPTISIDRFDRENLRARAYFLSHCHKDHMKGLRAPTLKRRLECSLKVYLY
CSPVTKELLLTSPKYRFWKKRIISIEIETPTQISLVDEASGEKEEIVVTLLPAGHCPGSV
MFLFQGNNGTVLYTGDFRLAQGEAARMELLHSGGRVKDIQSVYLDTTFCDPRFYQIPSRE
ECLSGVLELVRSWITRSPYHVVWLNCKAAYGYEYLFTNLSEELGVQVHVNKLDMFRNMPE
ILHHLTTDRNTQIHACRHPKAEEYFQWSKLPCGITSRNRIPLHIISIKPSTMWFGERSRK
TNVIVRTGESSYRACFSFHSSYSEIKDFLSYLCPVNAYPNVIPVGTTMDKVVEILKPLCR
SSQSTEPKYKPLGKLKRARTVHRDSEEEDDYLFDDPLPIPLRHKVPYPETFHPEVFSMTA
VSEKQPEKLRQTPGCCRAECMQSSRFTNFVDCEESNSESEEEVGIPASLQGDLGSVLHLQ
KADGDVPQWEVFFKRNDEITDESLENFPSSTVAGGSQSPKLFSDSDGESTHISSQNSSQS
THITEQGSQGWDSQSDTVLLSSQERNSGDITSLDKADYRPTIKENIPASLMEQNVICPKD
TYSDLKSRDKDVTIVPSTGEPTTLSSETHIPEEKSLLNLSTNADSQSSSDFEVPSTPEAE
LPKREHLQYLYEKLATGESIAVKKRKCSLLDT
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| BDBM32262 |
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| n/a |
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| Name | BDBM32262 |
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| Synonyms: | 5-benzyl-8-methyl-3-(methylthio)-[1,2,4]triazin[5,6-b]indole | 5-benzyl-8-methyl-3-methylsulfanyl-[1,2,4]triazino[5,6-b]indole | 8-methyl-3-(methylthio)-5-(phenylmethyl)-[1,2,4]triazino[5,6-b]indole | 8-methyl-3-methylsulfanyl-5-(phenylmethyl)-[1,2,4]triazino[5,6-b]indole | MLS000042505 | SMR000046397 | cid_6400963 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H16N4S |
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| Mol. Mass. | 320.411 |
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| SMILES | CSc1nnc2c3cc(C)ccc3n(Cc3ccccc3)c2n1 |
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| Structure | 
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