Ki Summary

Reaction Details

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Target

PC4 and SFRS1-interacting protein

Ligand

BDBM87457

Substrate/Competitor

n/a

Meas. Tech.

Counterscreen for inhibitors of LEDGF/p75-dependent integration: TR-FRET-based biochemical high throughput dose response counterscreen assay to identify activators of HIV-1 Integrase multimerization

IC50

3759±n/a nM

Citation

PubChem, PC Counterscreen for inhibitors of LEDGF/p75-dependent integration: TR-FRET-based biochemical high throughput dose response counterscreen assay to identify activators of HIV-1 Integrase multimerization PubChem Bioassay(2014)[AID]

More Info.:

Get all data from this article, Solution Info, Assay Method

PC4 and SFRS1-interacting protein

Name:

PC4 and SFRS1-interacting protein

Synonyms:

Type:

Enzyme Catalytic Domain

Mol. Mass.:

60120.68

Organism:

Homo sapiens (Human)

Description:

gi_6708281

Residue:

530

Sequence:

MTRDFKPGDLIFAKMKGYPHWPARVDEVPDGAVKPPTNKLPIFFFGTHETAFLGPKDIFP
YSENKEKYGKPNKRKGFNEGLWEIDNNPKVKFSSQQAATKQSNASSDVEVEEKETSVSKE
DTDHEEKASNEDVTKAVDITTPKAARRGRKRKAEKQVETEEAGVVTTATASVNLKVSPKR
GRPAATEVKIPKPRGRPKMVKQPCPSESDIITEEDKSKKKGQEEKQPKKQPKKDEEGQKE
EDKPRKEPDKKEGKKEVESKRKNLAKTGVTSTSDSEEEGDDQEGEKKRKGGRNFQTAHRR
NMLKGQHEKEAADRKRKQEEQMETEQQNKDEGKKPEVKKVEKKRETSMDSRLQRIHAEIK
NSLKIDNLDVNRCIEALDELASLQVTMQQAQKHTEMITTLKKIRRFKVSQVIMEKSTMLY
NKFKNMFLVGEGDSVITQVLNKSLAEQRQHEEANKTKDQGKKGPNKKLEKEQTGSKTLNG
GSDAQDGNQPQHNGESNEDSKDNHEASTKKKPSSEERETEISLKDSTLDN

BDBM87457

n/a

Name

BDBM87457

Synonyms:

1,4-Dicaffeylquinic acid | 1,4-bis[(E)-3-(3,4-dihydroxyphenyl)-1-oxoprop-2-enoxy]-3,5-dihydroxy-1-cyclohexanecarboxylic acid | 1,4-bis[[(E)-3-(3,4-dihydroxyphenyl)acryloyl]oxy]-3,5-dihydroxy-cyclohexanecarboxylic acid | 1,4-bis[[(E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxy]-3,5-dihydroxycyclohexane-1-carboxylic acid | 1,4-bis[[(E)-3-[3,4-bis(oxidanyl)phenyl]prop-2-enoyl]oxy]-3,5-bis(oxidanyl)cyclohexane-1-carboxylic acid | MLS000736925 | SMR000528430 | cid_5316647

Type

Small organic molecule

Emp. Form.

C25H24O12

Mol. Mass.

516.4509

SMILES

OC1CC(CC(O)C1OC(=O)\C=C\c1ccc(O)c(O)c1)(OC(=O)\C=C\c1ccc(O)c(O)c1)C(O)=O |(6.57,-.33,;7.91,.44,;7.91,1.98,;9.24,2.75,;10.58,1.98,;10.58,.44,;11.91,-.33,;9.24,-.33,;9.24,-1.87,;7.91,-2.64,;6.57,-1.87,;7.91,-4.18,;6.57,-4.95,;6.57,-6.49,;7.91,-7.26,;7.91,-8.8,;6.57,-9.57,;6.57,-11.11,;5.24,-8.8,;3.91,-9.57,;5.24,-7.26,;10.01,4.09,;11.55,4.09,;12.32,2.75,;12.32,5.42,;13.86,5.42,;14.63,6.76,;13.86,8.09,;14.63,9.42,;16.17,9.42,;16.94,10.76,;16.94,8.09,;18.48,8.09,;16.17,6.76,;8.47,4.09,;6.93,4.09,;9.24,5.42,)|

Structure