Reaction Details |
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Target | High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A |
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Ligand | BDBM50151526 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Scintillation Proximity Assay |
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pH | 8±n/a |
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IC50 | 140±n/a nM |
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Comments | extracted |
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Citation | Bergmann, JE; Cutshall, NS; Demopulos, GA; Florio, VA; Gaitanaris, G; Gray, P; Hohmann, J; Onrust, R; Zeng, H Use of PDE7 inhibitors for the treatment of movement disorders US Patent US8637528 Publication Date 1/28/2014 |
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More Info.: | Get all data from this article, Assay Method |
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High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A |
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Name: | High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A |
Synonyms: | 3',5'-cyclic phosphodiesterase | PDE7A | PDE7A_HUMAN | Phosphodiesterase 7 | Phosphodiesterase 7 (PDE7) | Phosphodiesterase 7A | Phosphodiesterase 7A (PDE7A1) |
Type: | Enzyme |
Mol. Mass.: | 55514.96 |
Organism: | Homo sapiens (Human) |
Description: | Q13946 |
Residue: | 482 |
Sequence: | MEVCYQLPVLPLDRPVPQHVLSRRGAISFSSSSALFGCPNPRQLSQRRGAISYDSSDQTA
LYIRMLGDVRVRSRAGFESERRGSHPYIDFRIFHSQSEIEVSVSARNIRRLLSFQRYLRS
SRFFRGTAVSNSLNILDDDYNGQAKCMLEKVGNWNFDIFLFDRLTNGNSLVSLTFHLFSL
HGLIEYFHLDMMKLRRFLVMIQEDYHSQNPYHNAVHAADVTQAMHCYLKEPKLANSVTPW
DILLSLIAAATHDLDHPGVNQPFLIKTNHYLATLYKNTSVLENHHWRSAVGLLRESGLFS
HLPLESRQQMETQIGALILATDISRQNEYLSLFRSHLDRGDLCLEDTRHRHLVLQMALKC
ADICNPCRTWELSKQWSEKVTEEFFHQGDIEKKYHLGVSPLCDRHTESIANIQIGFMTYL
VEPLFTEWARFSNTRLSQTMLGHVGLNKASWKGLQREQSSSEDTDAAFELNSQLLPQENR
LS
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BDBM50151526 |
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n/a |
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Name | BDBM50151526 |
Synonyms: | CHEMBL363097 | N-(4-{5-[(Z)-Cyclohexylimino]-4-methyl-4,5-dihydro-[1,3,4]thiadiazol-2-yl}-phenyl)-acetamide | US8637528, OM956 |
Type | Small organic molecule |
Emp. Form. | C17H22N4OS |
Mol. Mass. | 330.448 |
SMILES | CC(=O)Nc1ccc(cc1)-c1nn(C)\c(=N\C2CCCCC2)s1 |
Structure |
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