| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Macrophage colony-stimulating factor 1 receptor |
|---|
| Ligand | BDBM50443139 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Fluorescence Polarization Competition Assay |
|---|
| pH | 7.5±n/a |
|---|
| IC50 | 12.8±n/a nM |
|---|
| Comments | extracted |
|---|
| Citation |  Illig, CR; Ballentine, SK; Chen, J; DesJariais, RL; Meegalla, SK; Wall, M; Wilson, K Inhibitors of C-FMS kinase US Patent US8674100 Publication Date 3/18/2014 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Macrophage colony-stimulating factor 1 receptor |
|---|
| Name: | Macrophage colony-stimulating factor 1 receptor |
|---|
| Synonyms: | CSF1R_MOUSE | Csf1r | Csfmr | Fms | Macrophage colony-stimulating factor 1 receptor | Macrophage colony-stimulating factor 1 receptor (c-Fms) | Proto-oncogene c-Fms |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 109173.45 |
|---|
| Organism: | Mus musculus (Mouse) |
|---|
| Description: | P09581 |
|---|
| Residue: | 977 |
|---|
| Sequence: | MELGPPLVLLLATVWHGQGAPVIEPSGPELVVEPGETVTLRCVSNGSVEWDGPISPYWTL
DPESPGSTLTTRNATFKNTGTYRCTELEDPMAGSTTIHLYVKDPAHSWNLLAQEVTVVEG
QEAVLPCLITDPALKDSVSLMREGGRQVLRKTVYFFSPWRGFIIRKAKVLDSNTYVCKTM
VNGRESTSTGIWLKVNRVHPEPPQIKLEPSKLVRIRGEAAQIVCSATNAEVGFNVILKRG
DTKLEIPLNSDFQDNYYKKVRALSLNAVDFQDAGIYSCVASNDVGTRTATMNFQVVESAY
LNLTSEQSLLQEVSVGDSLILTVHADAYPSIQHYNWTYLGPFFEDQRKLEFITQRAIYRY
TFKLFLNRVKASEAGQYFLMAQNKAGWNNLTFELTLRYPPEVSVTWMPVNGSDVLFCDVS
GYPQPSVTWMECRGHTDRCDEAQALQVWNDTHPEVLSQKPFDKVIIQSQLPIGTLKHNMT
YFCKTHNSVGNSSQYFRAVSLGQSKQLPDESLFTPVVVACMSVMSLLVLLLLLLLYKYKQ
KPKYQVRWKIIERYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAF
GLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVI
TEYCCYGDLLNFLRRKAEAMLGPSLSPGQDSEGDSSYKNIHLEKKYVRRDSGFSSQGVDT
YVEMRPVSTSSSDSFFKQDLDKEASRPLELWDLLHFSSQVAQGMAFLASKNCIHRDVAAR
NVLLTSGHVAKIGDFGLARDIMNDSNYVVKGNARLPVKWMAPESIFDCVYTVQSDVWSYG
ILLWEIFSLGLNPYPGILVNNKFYKLVKDGYQMAQPVFAPKNIYSIMQSCWDLEPTRRPT
FQQICFLLQEQARLERRDQDYANLPSSGGSSGSDSGGGSSGGSSSEPEEESSSEHLACCE
PGDIAQPLLQPNNYQFC
|
|
|
|---|
| BDBM50443139 |
|---|
| n/a |
|---|
| Name | BDBM50443139 |
|---|
| Synonyms: | CHEMBL3085985 | US8674100, 32 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C22H25N5O4S |
|---|
| Mol. Mass. | 455.53 |
|---|
| SMILES | O=C(Nc1ccc(CS(=O)(=O)N2CCOCC2)cc1C1=CCCCC1)c1ncc([nH]1)C#N |t:21| |
|---|
| Structure | 
|
|---|
Search and Browse
