Reaction Details |
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Target | Arachidonate 5-lipoxygenase-activating protein |
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Ligand | BDBM283304 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Binding Assay |
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Ki | <0.1±n/a nM |
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Citation | Bacani, GM; Eccles, W; Fitzgerald, AE; Goldberg, SD; Hack, MD; Hawryluk, NA; Jones, WM; Keith, JM; Krawczuk, P; Lebsack, AD; Lee-Dutra, A; Liu, J; McClure, KJ; Meduna, SP; Pippel, DJ; Rosen, MD; Sales, ZS FLAP modulators US Patent US9884878 Publication Date 2/6/2018 |
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More Info.: | Get all data from this article, Assay Method |
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Arachidonate 5-lipoxygenase-activating protein |
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Name: | Arachidonate 5-lipoxygenase-activating protein |
Synonyms: | 5-lipoxygenase activating protein | 5-lipoxygenase-activating protein (FLAP) | 5-lipoxygenase/FLAP | AL5AP_HUMAN | ALOX5AP | FLAP | MK-886-binding protein |
Type: | Enzyme |
Mol. Mass.: | 18159.90 |
Organism: | Homo sapiens (Human) |
Description: | P20292 |
Residue: | 161 |
Sequence: | MDQETVGNVVLLAIVTLISVVQNGFFAHKVEHESRTQNGRSFQRTGTLAFERVYTANQNC
VDAYPTFLAVLWSAGLLCSQVPAAFAGLMYLFVRQKYFVGYLGERTQSTPGYIFGKRIIL
FLFLMSVAGIFNYYLIFFFGSDFENYIKTISTTISPLLLIP
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BDBM283304 |
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n/a |
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Name | BDBM283304 |
Synonyms: | 5-{3-Fluoro-2'-[(4-pyrimidin-2-ylpiperazin-1- yl)sulfonyl]biphenyl-4-yl}pyrazin-2-amine | US9745328, Compound 177 | US9884878, Compound 177 |
Type | Small organic molecule |
Emp. Form. | C24H22FN7O2S |
Mol. Mass. | 491.541 |
SMILES | Nc1cnc(cn1)-c1ccc(cc1F)-c1ccccc1S(=O)(=O)N1CCN(CC1)c1ncccn1 |
Structure |
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