Ki Summary

Reaction Details

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Target

D(2) dopamine receptor

Ligand

BDBM121480

Substrate/Competitor

n/a

Meas. Tech.

Radioligand Binding Assay

76.78±n/a nM

Citation

Rodriguez Sarmiento, RM; Wichmann, J Benzodioxole piperazine compounds US Patent US8722683 Publication Date 5/13/2014

More Info.:

Get all data from this article, Assay Method

D(2) dopamine receptor

Name:

D(2) dopamine receptor

Synonyms:

Type:

Cell-surface receptors

Mol. Mass.:

50647.10

Organism:

Homo sapiens (Human)

Description:

P14416

Residue:

443

Sequence:

MDPLNLSWYDDDLERQNWSRPFNGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVS
REKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTA
SILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVWVLSFTISCPLLFGLNNADQN
ECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRAHLRAPL
KGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRYSPIPP
SHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTSLKTMSR
RKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSA
VNPIIYTTFNIEFRKAFLKILHC

BDBM121480

n/a

Name

BDBM121480

Synonyms:

US8722683, 27

Type

Small organic molecule

Emp. Form.

C24H37N3O4

Mol. Mass.

431.5683

SMILES

CC(C)(O)CC(=O)N[C@H]1CC[C@H](CCN2CCN(CC2)c2cccc3OCOc23)CC1 |r,wU:8.7,wD:11.11,(9.73,-2.15,;8.96,-.82,;7.62,-1.59,;10.29,-.05,;8.19,.52,;6.65,.52,;5.88,-.82,;5.88,1.85,;4.34,1.85,;3.57,.52,;2.03,.52,;1.26,1.85,;-.28,1.85,;-1.05,.52,;-2.59,.52,;-3.36,-.82,;-4.9,-.82,;-5.67,.52,;-4.9,1.85,;-3.36,1.85,;-7.21,.52,;-7.98,1.85,;-9.52,1.85,;-10.29,.52,;-9.52,-.82,;-10,-2.28,;-8.75,-3.19,;-7.51,-2.28,;-7.98,-.82,;2.03,3.19,;3.57,3.19,)|

Structure