| Reaction Details |
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 | Report a problem with these data |
| Target | Dual specificity mitogen-activated protein kinase kinase 3 |
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| Ligand | BDBM103302 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Selectivity screening |
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| IC50 | 304±0.0 nM |
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| Citation |  Chaikuad, A; Tacconi, EM; Zimmer, J; Liang, Y; Gray, NS; Tarsounas, M; Knapp, S A unique inhibitor binding site in ER K1/2 is associated with slow binding kinetics Nat Chem Biol10:853-860 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Dual specificity mitogen-activated protein kinase kinase 3 |
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| Name: | Dual specificity mitogen-activated protein kinase kinase 3 |
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| Synonyms: | Dual specificity mitogen-activated protein kinase kinase 3 | MAP kinase kinase 3 | MAP2K3 | MAPK/ERK kinase 3 | MAPK/ERK kinase 3 (MEK3) | MAPKK 3 | MEK3 | MKK3 | MP2K3_HUMAN | PRKMK3 | SKK2 |
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| Type: | Protein |
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| Mol. Mass.: | 39321.50 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 347 |
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| Sequence: | MESPASSQPASMPQSKGKSKRKKDLRISCMSKPPAPNPTPPRNLDSRTFITIGDRNFEVE
ADDLVTISELGRGAYGVVEKVRHAQSGTIMAVKRIRATVNSQEQKRLLMDLDINMRTVDC
FYTVTFYGALFREGDVWICMELMDTSLDKFYRKVLDKNMTIPEDILGEIAVSIVRALEHL
HSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKTMDAGCKPYMAPERINPEL
NQKGYNVKSDVWSLGITMIEMAILRFPYESWGTPFQQLKQVVEEPSPQLPADRFSPEFVD
FTAQCLRKNPAERMSYLELMEHPFFTLHKTKKTDIAAFVKEILGEDS
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| BDBM103302 |
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| n/a |
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| Name | BDBM103302 |
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| Synonyms: | SCH772984 | US8546404, 6 |
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| Type | Small organic molecule |
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| Emp. Form. | C33H33N9O2 |
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| Mol. Mass. | 587.6742 |
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| SMILES | O=C(CN1CC[C@@H](C1)C(=O)Nc1ccc2[nH]nc(-c3ccncc3)c2c1)N1CCN(CC1)c1ccc(cc1)-c1ncccn1 |r| |
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| Structure | 
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