| Reaction Details |
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 | Report a problem with these data |
| Target | Urease [D459Y,K653P] |
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| Ligand | BDBM123720 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Urease Inhibition Assay |
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| Temperature | 303.15±0 K |
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| IC50 | 4.10e+4± 1.3e+3 nM |
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| Citation |  Akhtar, T; Khan, MA; Iqbal, J; Jones, PG; Hameed, S A facile one-pot synthesis of 2-arylamino-5-aryloxylalkyl-1,3,4-oxadiazoles and their urease inhibition studies. Chem Biol Drug Des84:92-8 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Urease [D459Y,K653P] |
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| Name: | Urease [D459Y,K653P] |
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| Synonyms: | UREA_CANEN | Urea amidohydrolase | Urease |
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| Type: | Protein |
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| Mol. Mass.: | 90763.23 |
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| Organism: | Canavalia ensiformis (Jack bean) |
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| Description: | P07374[D459Y,K653P] |
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| Residue: | 840 |
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| Sequence: | MKLSPREVEKLGLHNAGYLAQKRLARGVRLNYTEAVALIASQIMEYARDGEKTVAQLMCL
GQHLLGRRQVLPAVPHLLNAVQVEATFPDGTKLVTVHDPISRENGELQEALFGSLLPVPS
LDKFAETKEDNRIPGEILCEDECLTLNIGRKAVILKVTSKGDRPIQVGSHYHFIEVNPYL
TFDRRKAYGMRLNIAAGTAVRFEPGDCKSVTLVSIEGNKVIRGGNAIADGPVNETNLEAA
MHAVRSKGFGHEEEKDASEGFTKEDPNCPFNTFIHRKEYANKYGPTTGDKIRLGDTNLLA
EIEKDYALYGDECVFGGGKVIRDGMGQSCGHPPAISLDTVITNAVIIDYTGIIKADIGIK
DGLIASIGKAGNPDIMNGVFSNMIIGANTEVIAGEGLIVTAGAIDCHVHYICPQLVYEAI
SSGITTLVGGGTGPAAGTRATTCTPSPTQMRLMLQSTDYLPLNFGFTGKGSSSKPDELHE
IIKAGAMGLKLHEDWGSTPAAIDNCLTIAEHHDIQINIHTDTLNEAGFVEHSIAAFKGRT
IHTYHSEGAGGGHAPDIIKVCGIKNVLPSSTNPTRPLTSNTIDEHLDMLMVCHHLDREIP
EDLAFAHSRIRKKTIAAEDVLNDIGAISIISSDSQAMGRVGEVISRTWQTADPMKAQTGP
LKCDSSDNDNFRIRRYIAKYTINPAIANGFSQYVGSVEVGKLADLVMWKPSFFGTKPEMV
IKGGMVAWADIGDPNASIPTPEPVKMRPMYGTLGKAGGALSIAFVSKAALDQRVNVLYGL
NKRVEAVSNVRKLTKLDMKLNDALPEITVDPESYTVKADGKLLCVSEATTVPLSRNYFLF
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| BDBM123720 |
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| n/a |
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| Name | BDBM123720 |
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| Synonyms: | 2-(4-Methylphenyl)amino-5-(1-(3,4-dichlorophenoxy)ethyl)-1,3,4-oxadiazole (3d) |
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| Type | Small organic molecule |
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| Emp. Form. | C17H15Cl2N3O2 |
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| Mol. Mass. | 364.226 |
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| SMILES | CC(Oc1ccc(Cl)c(Cl)c1)c1nnc(Nc2ccc(C)cc2)o1 |
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| Structure | 
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