| Reaction Details |
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 | Report a problem with these data |
| Target | Rhodopsin kinase GRK1 |
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| Ligand | BDBM284001 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Assays for Inhibition of GRKs |
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| pH | 7±n/a |
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| IC50 | 14000±n/a nM |
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| Comments | extracted |
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| Citation |  Larsen, SD; Homan, K; Waldschmidt, H; Tesmer, JJ G protein-coupled receptor kinase 2 inhibitors and methods for use of the same US Patent US10023564 Publication Date 7/17/2018 |
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| More Info.: | Get all data from this article, Assay Method |
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| Rhodopsin kinase GRK1 |
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| Name: | Rhodopsin kinase GRK1 |
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| Synonyms: | G protein-coupled receptor kinase 1 | GRK1 | GRK1_HUMAN | PK | RHOK | Rhodopsin kinase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 63520.09 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_774378 |
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| Residue: | 563 |
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| Sequence: | MDFGSLETVVANSAFIAARGSFDGSSSQPSRDKKYLAKLKLPPLSKCESLRDSLSLEFES
VCLEQPIGKKLFQQFLQSAEKHLPALELWKDIEDYDTADNDLQPQKAQTILAQYLDPQAK
LFCSFLDEGIVAKFKEGPVEIQDGLFQPLLQATLAHLGQAPFQEYLGSLYFLRFLQWKWL
EAQPMGEDWFLDFRVLGKGGFGEVSACQMKATGKLYACKKLNKKRLKKRKGYQGAMVEKK
ILMKVHSRFIVSLAYAFETKADLCLVMTIMNGGDIRYHIYNVNEENPGFPEPRALFYTAQ
IICGLEHLHQRRIVYRDLKPENVLLDNDGNVRISDLGLAVELLDGQSKTKGYAGTPGFMA
PELLQGEEYDFSVDYFALGVTLYEMIAARGPFRARGEKVENKELKHRIISEPVKYPDKFS
QASKDFCEALLEKDPEKRLGFRDETCDKLRAHPLFKDLNWRQLEAGMLMPPFIPDSKTVY
AKDIQDVGAFSTVKGVAFDKTDTEFFQEFATGNCPIPWQEEMIETGIFGELNVWRSDGQM
PDDMKGISGGSSSSSKSGMCLVS
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| BDBM284001 |
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| n/a |
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| Name | BDBM284001 |
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| Synonyms: | E27 | US10023564, Example 27 |
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| Type | Small organic molecule |
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| Emp. Form. | C29H27FN6O4 |
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| Mol. Mass. | 542.5609 |
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| SMILES | COc1ccccc1C(C)NC(=O)c1cc(ccc1F)C1NC(=O)NC(C)=C1C(=O)Nc1ccc2[nH]ncc2c1 |c:28| |
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| Structure | 
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