| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosine-protein kinase SYK |
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| Ligand | BDBM124628 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Homogeneous Time-Resolved Fluorescence (HTRF) Assay |
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| pH | 7.5±n/a |
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| Temperature | 298.15±n/a K |
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| IC50 | 2±n/a nM |
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| Comments | extracted |
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| Citation |  Childers, KK; Haidle, AM; Machacek, MR; Northrup, AB Aminopyrimidines as SYK inhibitors US Patent US8759366 Publication Date 6/24/2014 |
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| More Info.: | Get all data from this article, Assay Method |
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| Tyrosine-protein kinase SYK |
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| Name: | Tyrosine-protein kinase SYK |
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| Synonyms: | KSYK_HUMAN | SYK | Spleen Tyrosine Kinase | Spleen tyrosine kinase (SYK) | Tyrosine-protein kinase SYK (Syk) |
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| Type: | Enzyme |
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| Mol. Mass.: | 72079.99 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P43405 |
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| Residue: | 635 |
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| Sequence: | MASSGMADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRK
AHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPF
EDLKENLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQ
IVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQL
VEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPATWSAGGIISRIKSYSFPK
PGHRKSSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRP
KEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAE
ANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSM
GMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYA
PECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPRE
MYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN
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| BDBM124628 |
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| n/a |
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| Name | BDBM124628 |
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| Synonyms: | US8759366, (1S,4R)-N-(cyanomethyl)-4-hydroxy-2,2-dimethyl-4-(5-{3-methyl-5-[(4-methylpyrimidin-2-yl)amino]phenyl}-1,3-thiazol-2-yl)cyclohexanecarboxamide |
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| Type | Small organic molecule |
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| Emp. Form. | C26H30N6O2S |
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| Mol. Mass. | 490.62 |
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| SMILES | Cc1cc(Nc2nccc(C)n2)cc(c1)-c1cnc(s1)[C@@]1(O)CC[C@H](C(=O)NCC#N)C(C)(C)C1 |
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| Structure | 
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