| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosine-protein phosphatase non-receptor type 6 |
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| Ligand | BDBM125930 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Inhibitory Assay |
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| pH | 6.5±n/a |
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| IC50 | >8.0e+4±n/a nM |
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| Comments | extracted |
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| Citation |  Luo, L; He, XP; Shen, Q; Li, JY; Shi, XX; Xie, J; Li, J; Chen, GR Synthesis of (glycopyranosyl-triazolyl)-purines and their inhibitory activities against protein tyrosine phosphatase 1B (PTP1B). Chem Biodivers8:2035-44 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Tyrosine-protein phosphatase non-receptor type 6 |
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| Name: | Tyrosine-protein phosphatase non-receptor type 6 |
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| Synonyms: | HCP | PTN6_HUMAN | PTP1C | PTPN6 | Protein tyrosine phosphatase SHP-1 (SHP-1) | Protein-tyrosine phosphatase 1C | Protein-tyrosine phosphatase SHP-1 | Src homology phosphatase 1 (SHP-1) | Tyrosine-protein phosphatase non-receptor type 6 | Tyrosine-protein phosphatase non-receptor type 6 (SHP1) |
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| Type: | Protein |
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| Mol. Mass.: | 67570.41 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P29350 |
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| Residue: | 595 |
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| Sequence: | MVRWFHRDLSGLDAETLLKGRGVHGSFLARPSRKNQGDFSLSVRVGDQVTHIRIQNSGDF
YDLYGGEKFATLTELVEYYTQQQGVLQDRDGTIIHLKYPLNCSDPTSERWYHGHMSGGQA
ETLLQAKGEPWTFLVRESLSQPGDFVLSVLSDQPKAGPGSPLRVTHIKVMCEGGRYTVGG
LETFDSLTDLVEHFKKTGIEEASGAFVYLRQPYYATRVNAADIENRVLELNKKQESEDTA
KAGFWEEFESLQKQEVKNLHQRLEGQRPENKGKNRYKNILPFDHSRVILQGRDSNIPGSD
YINANYIKNQLLGPDENAKTYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNK
CVPYWPEVGMQRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDNGDLIREIWHYQYLSWPDH
GVPSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGLDC
DIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIETTKKKLEVLQSQKGQESEYGNIT
YPPAMKNAHAKASRTSSKHKEDVYENLHTKNKREEKVKKQRSADKEKSKGSLKRK
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| BDBM125930 |
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| n/a |
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| Name | BDBM125930 |
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| Synonyms: | 6-Chloro-9-{[1-(2,3,4,6-tetra-O-acetyl-b-d-glucopyranosyl)-1H-1,2,3-triazol-4-yl]methyl}-2-({[1- (2,3,4,6-tetra-O-acetyl-b-d-glucopyranosyl)-1H-1,2,3-triazol-4-yl]methyl}amino)-9H-purine (8) |
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| Type | Small organic molecule |
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| Emp. Form. | C39H46ClN11O18 |
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| Mol. Mass. | 992.298 |
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| SMILES | CC(=O)OC[C@H]1O[C@@H]([C@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]1OC(C)=O)n1cc(CNc2nc(Cl)c3ncn(Cc4cn(nn4)[C@H]4O[C@H](COC(C)=O)[C@@H](OC(C)=O)[C@H](OC(C)=O)[C@H]4OC(C)=O)c3n2)nn1 |
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| Structure | 
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