Reaction Details |
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Target | Sphingosine 1-phosphate receptor 1 |
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Ligand | BDBM127526 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Receptor Calcium FLIPR Antagonist Assay |
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Temperature | 310.15±n/a K |
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IC50 | 1.9±n/a nM |
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Comments | extracted |
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Citation | Angst, D; Bollbuck, B; Janser, P; Quancard, J; Stiefl, NJ Aryl benzylamine compounds US Patent US8791100 Publication Date 7/29/2014 |
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More Info.: | Get all data from this article, Assay Method |
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Sphingosine 1-phosphate receptor 1 |
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Name: | Sphingosine 1-phosphate receptor 1 |
Synonyms: | CHEDG1 | EDG1 | Endothelial differentiation G-protein coupled receptor 1 | S1P receptor | S1P1 | S1PR1 | S1PR1_HUMAN | Sphingosine 1-phosphate receptor 1 (S1PR1) | Sphingosine 1-phosphate receptor Edg-1 |
Type: | Enzyme |
Mol. Mass.: | 42836.02 |
Organism: | Homo sapiens (Human) |
Description: | P21453 |
Residue: | 382 |
Sequence: | MGPTSVPLVKAHRSSVSDYVNYDIIVRHYNYTGKLNISADKENSIKLTSVVFILICCFII
LENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYTANLLLSGATTYKLTPAQWFLR
EGSMFVALSASVFSLLAIAIERYITMLKMKLHNGSNNFRLFLLISACWVISLILGGLPIM
GWNCISALSSCSTVLPLYHKHYILFCTTVFTLLLLSIVILYCRIYSLVRTRSRRLTFRKN
ISKASRSSEKSLALLKTVIIVLSVFIACWAPLFILLLLDVGCKVKTCDILFRAEYFLVLA
VLNSGTNPIIYTLTNKEMRRAFIRIMSCCKCPSGDSAGKFKRPIIAGMEFSRSKSDNSSH
PQKDEGDNPETIMSSGNVNSSS
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BDBM127526 |
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n/a |
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Name | BDBM127526 |
Synonyms: | US8791100, 24 |
Type | Small organic molecule |
Emp. Form. | C21H24ClFN2O2 |
Mol. Mass. | 390.879 |
SMILES | CC[C@@H](Nc1cccc(CN2CC(C2)C(O)=O)c1F)c1ccc(Cl)c(C)c1 |r| |
Structure |
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