| Reaction Details |
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 | Report a problem with these data |
| Target | RNA-editing ligase 1, mitochondrial |
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| Ligand | BDBM50393 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Fluorescence-based biochemical high throughput dose response assay to identify inhibitors of Trypanosoma brucei RNA editing ligase 1 (TbREL1). |
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| IC50 | 63585±n/a nM |
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| Citation |  PubChem, PC Fluorescence-based biochemical high throughput dose response assay to identify inhibitors of Trypanosoma brucei RNA editing ligase 1 (TbREL1). PubChem Bioassay(2014)[AID] |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| RNA-editing ligase 1, mitochondrial |
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| Name: | RNA-editing ligase 1, mitochondrial |
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| Synonyms: | REL1 | RLGM1_TRYBB | Trypanosoma brucei RNA editing ligase 1 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 52299.36 |
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| Organism: | Trypanosoma brucei brucei |
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| Description: | gi_342179211 |
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| Residue: | 469 |
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| Sequence: | MQLQRLGAPLLKRLVGGCIRQSTAPIMPCVVVSGSGVFLTPVRTYMPLPNDQSDFSPYIE
IDLPSESRIQSLHKSGLAAQEWVACEKVHGTNFGIYLINQGDHEVVRFAKRSGIMDPNEN
FFGYHILIDEFTAQIRILNDLLKQKYGLSRVGRLVLNGELFGAKYKHPLVPKSEKWCTLP
NGKKFPIAGVQIQREPFPQYSPELHFFAFDIKYSVSGAEEDFVLLGYDEFVEFSSKVPNL
LYARALVRGTLDECLAFDVENFMTPLPALLGLGNYPLEGNLAEGVVIRHVRRGDPAVEKH
NVSTIIKLRCSSFMELKHPGKQKELKETFIDTVRSGALRRVRGNVTVISDSMLPQVEAAA
NDLLLNNVSDGRLSNVLSKIGREPLLSGEVSQVDVVLMLAKDALKDFLKEVDSLVLNTTL
AFRKLLITNVYFESKRLVEQKWKELMQEEAAAQSEAIPPLSPAAPTKGE
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| BDBM50393 |
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| n/a |
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| Name | BDBM50393 |
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| Synonyms: | (E)-N,N'-bis(5-keto-6-methyl-3-thioxo-2H-1,2,4-triazin-4-yl)but-2-enediamide | (E)-N,N'-bis(6-methyl-5-oxidanylidene-3-sulfanylidene-2H-1,2,4-triazin-4-yl)but-2-enediamide | (E)-N,N'-bis(6-methyl-5-oxo-3-sulfanylidene-2H-1,2,4-triazin-4-yl)-2-butenediamide | (E)-N,N'-bis(6-methyl-5-oxo-3-sulfanylidene-2H-1,2,4-triazin-4-yl)but-2-enediamide | MLS000699312 | N~1~,N~4~-bis(6-methyl-5-oxo-3-thioxo-2,5-dihydro-1,2,4-triazin-4(3H)-yl)-2-butenediamide | SMR000229795 | cid_1818352 |
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| Type | Small organic molecule |
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| Emp. Form. | C12H12N8O4S2 |
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| Mol. Mass. | 396.405 |
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| SMILES | Cc1n[nH]c(=S)n(NC(=O)C=CC(=O)Nn2c(=S)[nH]nc(C)c2=O)c1=O |w:10.9| |
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| Structure | 
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