Ki Summary

Reaction Details

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Target

RNA-editing ligase 1, mitochondrial

Ligand

BDBM32033

Substrate/Competitor

n/a

Meas. Tech.

Fluorescence-based biochemical high throughput dose response assay to identify inhibitors of Trypanosoma brucei RNA editing ligase 1 (TbREL1).

IC50

21763±n/a nM

Citation

PubChem, PC Fluorescence-based biochemical high throughput dose response assay to identify inhibitors of Trypanosoma brucei RNA editing ligase 1 (TbREL1). PubChem Bioassay(2014)[AID]

More Info.:

Get all data from this article, Solution Info, Assay Method

RNA-editing ligase 1, mitochondrial

Name:

RNA-editing ligase 1, mitochondrial

Synonyms:

REL1 | RLGM1_TRYBB | Trypanosoma brucei RNA editing ligase 1

Type:

Enzyme Catalytic Domain

Mol. Mass.:

52299.36

Organism:

Trypanosoma brucei brucei

Description:

gi_342179211

Residue:

469

Sequence:

MQLQRLGAPLLKRLVGGCIRQSTAPIMPCVVVSGSGVFLTPVRTYMPLPNDQSDFSPYIE
IDLPSESRIQSLHKSGLAAQEWVACEKVHGTNFGIYLINQGDHEVVRFAKRSGIMDPNEN
FFGYHILIDEFTAQIRILNDLLKQKYGLSRVGRLVLNGELFGAKYKHPLVPKSEKWCTLP
NGKKFPIAGVQIQREPFPQYSPELHFFAFDIKYSVSGAEEDFVLLGYDEFVEFSSKVPNL
LYARALVRGTLDECLAFDVENFMTPLPALLGLGNYPLEGNLAEGVVIRHVRRGDPAVEKH
NVSTIIKLRCSSFMELKHPGKQKELKETFIDTVRSGALRRVRGNVTVISDSMLPQVEAAA
NDLLLNNVSDGRLSNVLSKIGREPLLSGEVSQVDVVLMLAKDALKDFLKEVDSLVLNTTL
AFRKLLITNVYFESKRLVEQKWKELMQEEAAAQSEAIPPLSPAAPTKGE

BDBM32033

n/a

Name

BDBM32033

Synonyms:

1-butyl-2-(2-furoylamino)pyrrolo[3,2-b]quinoxaline-3-carboxylic acid ethyl ester | 1-butyl-2-[[2-furanyl(oxo)methyl]amino]-3-pyrrolo[3,2-b]quinoxalinecarboxylic acid ethyl ester | MLS000079916 | SMR000040037 | cid_659124 | ethyl 1-butyl-2-(furan-2-carbonylamino)pyrrolo[3,2-b]quinoxaline-3-carboxylate | ethyl 1-butyl-2-(furan-2-ylcarbonylamino)pyrrolo[3,2-b]quinoxaline-3-carboxylate

Type

Small organic molecule

Emp. Form.

C22H22N4O4

Mol. Mass.

406.4345

SMILES

CCCCn1c(NC(=O)c2ccco2)c(C(=O)OCC)c2nc3ccccc3nc12

Structure