| Reaction Details |
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 | Report a problem with these data |
| Target | Transthyretin |
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| Ligand | BDBM128233 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Counterscreen for activators of Transthyretin (TTR) transcription: Luminescence-based cell-based high throughput dose response assay to identify inhibitors of Transthyretin (TTR) transcription in HuH7 |
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| IC50 | 90915±n/a nM |
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| Citation |  PubChem, PC Counterscreen for activators of Transthyretin (TTR) transcription: Luminescence-based cell-based high throughput dose response assay to identify inhibitors of Transthyretin (TTR) transcription in HuH7 hepatoma cells PubChem Bioassay(2014)[AID] |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Transthyretin |
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| Name: | Transthyretin |
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| Synonyms: | ATTR | PALB | Prealbumin | TBPA | TTHY_HUMAN | TTR | Transthyretin (TTR) |
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| Type: | Enzyme |
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| Mol. Mass.: | 15884.31 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P02766 |
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| Residue: | 147 |
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| Sequence: | MASHRLLLLCLAGLVFVSEAGPTGTGESKCPLMVKVLDAVRGSPAINVAVHVFRKAADDT
WEPFASGKTSESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDS
GPRRYTIAALLSPYSYSTTAVVTNPKE
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| BDBM128233 |
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| n/a |
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| Name | BDBM128233 |
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| Synonyms: | (5Z)-5-[(E)-3-(1,3-benzodioxol-5-yl)-1-hydroxy-prop-2-enylidene]-1-butyl-barbituric acid | (5Z)-5-[(E)-3-(1,3-benzodioxol-5-yl)-1-hydroxyprop-2-enylidene]-1-butyl-1,3-diazinane-2,4,6-trione | (5Z)-5-[(E)-3-(1,3-benzodioxol-5-yl)-1-oxidanyl-prop-2-enylidene]-1-butyl-1,3-diazinane-2,4,6-trione | 5-((E)-3-Benzo[1,3]dioxol-5-yl-acryloyl)-3-butyl-6-hydroxy-1H-pyrimidine-2,4-dione | MLS000763033 | SMR000439468 | cid_54677751 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H18N2O6 |
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| Mol. Mass. | 358.3453 |
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| SMILES | CCCCN1C(=O)NC(=O)\C(=C(\O)/C=C/c2ccc3OCOc3c2)C1=O |
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| Structure | 
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