Ki Summary

Reaction Details

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Target

D(3) dopamine receptor

Ligand

BDBM129719

Substrate/Competitor

n/a

Meas. Tech.

Receptor Binding Assay

2±n/a nM

Citation

Szalai, GB; Csongor, EA; Domany, G; Gyertyan, I; Kiss, B; Laszy, J; Saghy, K; Schmidt, E; Farkas, S; Komlodi, Z Pyrimidinyl-piperazines useful as D3/D2 receptor ligands US Patent US8802672 Publication Date 8/12/2014

More Info.:

Get all data from this article, Assay Method

D(3) dopamine receptor

Name:

D(3) dopamine receptor

Synonyms:

DOPAMINE D3 | DRD3_RAT | Dopamine D3 receptor | Drd3

Type:

Protein

Mol. Mass.:

49540.58

Organism:

Rattus norvegicus (Rat)

Description:

P19020

Residue:

446

Sequence:

MAPLSQISTHLNSTCGAENSTGVNRARPHAYYALSYCALILAIIFGNGLVCAAVLRERAL
QTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILN
LCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPSI
CSISNPDFVIYSSVVSFYVPFGVTVLVYARIYIVLRQRQRKRILTRQNSQCISIRPGFPQ
QSSCLRLHPIRQFSIRARFLSDATGQMEHIEDKQYPQKCQDPLLSHLQPPSPGQTHGGLK
RYYSICQDTALRHPSLEGGAGMSPVERTRNSLSPTMAPKLSLEVRKLSNGRLSTSLRLGP
LQPRGVPLREKKATQMVVIVLGAFIVCWLPFFLTHVLNTHCQACHVSPELYRATTWLGYV
NSALNPVIYTTFNVEFRKAFLKILSC

BDBM129719

n/a

Name

BDBM129719

Synonyms:

US8802672, 7

Type

Small organic molecule

Emp. Form.

C22H35Cl2N7O2

Mol. Mass.

500.465

SMILES

CNc1nc(Cl)c(Cl)c(n1)N1CCN(CCC2CCC(CC2)NC(=O)N2CCOCC2)CC1 |(-4.53,8.84,;-3.2,9.61,;-1.86,8.84,;-.53,9.61,;.81,8.84,;2.14,9.61,;.81,7.3,;2.14,6.53,;-.53,6.53,;-1.86,7.3,;-.53,4.99,;-1.86,4.22,;-1.86,2.68,;-.53,1.91,;-.53,.37,;.81,-.4,;.81,-1.94,;-.53,-2.71,;-.53,-4.25,;.81,-5.02,;2.14,-4.25,;2.14,-2.71,;.81,-6.56,;2.14,-7.33,;3.47,-6.56,;2.14,-8.87,;3.47,-9.64,;3.47,-11.18,;2.14,-11.95,;.81,-11.18,;.81,-9.64,;.81,2.68,;.81,4.22,)|

Structure