Ki Summary

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Target

cAMP-specific 3',5'-cyclic phosphodiesterase 4B [122-736,S654A]

Ligand

BDBM285546

Substrate/Competitor

n/a

Meas. Tech.

The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays

IC50

13.6±n/a nM

Citation

Chappie, TA; Patel, NC; Hayward, MM; Helal, CJ; Sciabola, S; LaChapelle, EA; Young, JM; Verhoest, PR Imidazopyridazine compounds US Patent US10077269 Publication Date 9/18/2018

More Info.:

Get all data from this article, Assay Method

cAMP-specific 3',5'-cyclic phosphodiesterase 4B [122-736,S654A]

Name:

cAMP-specific 3',5'-cyclic phosphodiesterase 4B [122-736,S654A]

Synonyms:

DPDE4 | PDE4B | PDE4B1 | PDE4B_HUMAN | cAMP-specific 3',5'-cyclic phosphodiesterase 4B

Type:

Enzyme Catalytic Domain

Mol. Mass.:

70253.85

Organism:

Homo sapiens (Human)

Description:

Q07343[122-736,S654A]

Residue:

615

Sequence:

ATFPGHSQRREEFLYRSDSDYDLSPKAMSRNSSLPSEQHGDDLIVTPFAQVLASLRSVRN
NFTILTNLHGTSNKRSPAASQPPVSRVNPQEESYQKLAMETLEELDWCLDQLETIQTYRS
VSEMASNKFKRMLNRELTHLSEMSRSGNQVSEYISNTFLDKQNDVEIPSPTQKDREKKKK
QQLMTQISGVKKLMHSSSLNNTSISRFGVNTENEDHLAKELEDLNKWGLNIFNVAGYSHN
RPLTCIMYAIFQERDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHVL
LSTPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLA
VGFKLLQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSS
GVLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEIS
PMCDKHTASVEKSQVGFIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWYQAMIPQAPA
PPLDEQNRDCQGLMEKFQFELTLDEEDSEGPEKEGEGHSYFSSTKTLCVIDPENRDSLGE
TDIDIATEDKSPVDT

BDBM285546

n/a

Name

BDBM285546

Synonyms:

3-(4-cyano-5-fluoro-2-methylphenyl)-N-cyclo-propylimidazo[1,2-b]pyridazine-2-carboxamide | US10077269, Example 19 | US10669279, Example 19 | US9598421, Example 19

Type

Small organic molecule

Emp. Form.

C18H14FN5O

Mol. Mass.

335.3351

SMILES

Cc1cc(C#N)c(F)cc1-c1c(nc2cccnn12)C(=O)NC1CC1 |(2.81,-8.2,;4.3,-7.8,;4.7,-6.31,;6.18,-5.91,;6.58,-4.42,;6.9,-2.92,;7.27,-7,;8.76,-6.6,;6.88,-8.49,;5.39,-8.89,;4.99,-10.37,;5.89,-11.62,;4.99,-12.87,;3.52,-12.39,;2.19,-13.16,;.86,-12.39,;.86,-10.85,;2.19,-10.08,;3.52,-10.85,;7.43,-11.62,;8.2,-10.29,;8.2,-12.95,;9.74,-12.95,;11.08,-13.72,;11.08,-12.18,)|

Structure