Reaction Details |
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Target | Isoform 4 of cAMP-specific 3',5'-cyclic phosphodiesterase 4A (RD1) |
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Ligand | BDBM285550 |
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Substrate/Competitor | n/a |
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Meas. Tech. | The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays |
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IC50 | 15.1±n/a nM |
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Citation | Chappie, TA; Patel, NC; Hayward, MM; Helal, CJ; Sciabola, S; LaChapelle, EA; Young, JM; Verhoest, PR Imidazopyridazine compounds US Patent US10077269 Publication Date 9/18/2018 |
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More Info.: | Get all data from this article, Assay Method |
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Isoform 4 of cAMP-specific 3',5'-cyclic phosphodiesterase 4A (RD1) |
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Name: | Isoform 4 of cAMP-specific 3',5'-cyclic phosphodiesterase 4A (RD1) |
Synonyms: | DPDE2 | PDE4A | PDE4A1 | PDE4A_HUMAN | Phosphodiesterase 4A (PDE4A1) | Phosphodiesterase 4A1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4A (RD1) | cAMP-specific 3',5'-cyclic phosphodiesterase 4A Isoform 4 |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 72186.86 |
Organism: | Homo sapiens (Human) |
Description: | P27815-4 |
Residue: | 647 |
Sequence: | MPLVDFFCETCSKPWLVGWWDQFKRMLNRELTHLSEMSRSGNQVSEYISTTFLDKQNEVE
IPSPTMKEREKQQAPRPRPSQPPPPPVPHLQPMSQITGLKKLMHSNSLNNSNIPRFGVKT
DQEELLAQELENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYM
LTLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPG
VSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVID
MVLATDMSKHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPL
ELYRQWTDRIMAEFFQQGDRERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWAD
LVHPDAQEILDTLEDNRDWYYSAIRQSPSPPPEEESRGPGHPPLPDKFQFELTLEEEEEE
EISMAQIPCTAQEALTAQGLSGVEEALDATIAWEASPAQESLEVMAQEASLEAELEAVYL
TQQAQSTGSAPVAPDEFSSREEFVVAVSHSSPSALALQSPLLPAWRTLSVSEHAPGLPGL
PSTAAEVEAQREHQAAKRACSACAGTFGEDTSALPAPGGGGSGGDPT
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BDBM285550 |
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n/a |
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Name | BDBM285550 |
Synonyms: | 4-[2-(azetidin-1-ylcarbonyl)imidazo[1,2-b]pyridazin-3-yl]-2-fluorobenzonitrile | US10077269, Example 23 | US10669279, Example 23 | US9598421, Example 23 |
Type | Small organic molecule |
Emp. Form. | C17H12FN5O |
Mol. Mass. | 321.3085 |
SMILES | Fc1cc(ccc1C#N)-c1c(nc2cccnn12)C(=O)N1CCC1 |
Structure |
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