Reaction Details | |||
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Target | Isoform 4 of cAMP-specific 3',5'-cyclic phosphodiesterase 4A (RD1) | ||
Ligand | BDBM285567 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays | ||
IC50 | 19.6±n/a nM | ||
Citation | Chappie, TA; Patel, NC; Hayward, MM; Helal, CJ; Sciabola, S; LaChapelle, EA; Young, JM; Verhoest, PR Imidazopyridazine compounds US Patent US10077269 Publication Date 9/18/2018 | ||
More Info.: | Get all data from this article, Assay Method | ||
Isoform 4 of cAMP-specific 3',5'-cyclic phosphodiesterase 4A (RD1) | |||
Name: | Isoform 4 of cAMP-specific 3',5'-cyclic phosphodiesterase 4A (RD1) | ||
Synonyms: | DPDE2 | PDE4A | PDE4A1 | PDE4A_HUMAN | Phosphodiesterase 4A (PDE4A1) | Phosphodiesterase 4A1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4A (RD1) | cAMP-specific 3',5'-cyclic phosphodiesterase 4A Isoform 4 | ||
Type: | Enzyme Catalytic Domain | ||
Mol. Mass.: | 72186.86 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P27815-4 | ||
Residue: | 647 | ||
Sequence: |
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BDBM285567 | |||
n/a | |||
Name | BDBM285567 | ||
Synonyms: | 3-(4-chloro-2-fluorophenyl)-N-cyclopropylimidazo[1,2-b]pyridazine-2-carboxamide | US10077269, Example 40 | US10669279, Example 40 | US9598421, Example 40 | ||
Type | Small organic molecule | ||
Emp. Form. | C16H12ClFN4O | ||
Mol. Mass. | 330.744 | ||
SMILES | Fc1cc(Cl)ccc1-c1c(nc2cccnn12)C(=O)NC1CC1 |(-3.16,.88,;-1.67,1.28,;-1.27,2.76,;.22,3.16,;.62,4.65,;1.31,2.07,;.91,.59,;-.58,.19,;-.98,-1.3,;-.07,-2.55,;-.98,-3.79,;-2.44,-3.32,;-3.78,-4.09,;-5.11,-3.32,;-5.11,-1.78,;-3.78,-1.01,;-2.44,-1.78,;1.47,-2.55,;2.24,-1.21,;2.24,-3.88,;3.78,-3.88,;5.11,-4.65,;5.11,-3.11,)| | ||
Structure |