Ki Summary

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Target

cAMP-specific 3',5'-cyclic phosphodiesterase 4B [122-736,S654A]

Ligand

BDBM285567

Substrate/Competitor

n/a

Meas. Tech.

The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays

IC50

65.3±n/a nM

Citation

Chappie, TA; Patel, NC; Hayward, MM; Helal, CJ; Sciabola, S; LaChapelle, EA; Young, JM; Verhoest, PR Imidazopyridazine compounds US Patent US10077269 Publication Date 9/18/2018

More Info.:

Get all data from this article, Assay Method

cAMP-specific 3',5'-cyclic phosphodiesterase 4B [122-736,S654A]

Name:

cAMP-specific 3',5'-cyclic phosphodiesterase 4B [122-736,S654A]

Synonyms:

DPDE4 | PDE4B | PDE4B1 | PDE4B_HUMAN | cAMP-specific 3',5'-cyclic phosphodiesterase 4B

Type:

Enzyme Catalytic Domain

Mol. Mass.:

70253.85

Organism:

Homo sapiens (Human)

Description:

Q07343[122-736,S654A]

Residue:

615

Sequence:

ATFPGHSQRREEFLYRSDSDYDLSPKAMSRNSSLPSEQHGDDLIVTPFAQVLASLRSVRN
NFTILTNLHGTSNKRSPAASQPPVSRVNPQEESYQKLAMETLEELDWCLDQLETIQTYRS
VSEMASNKFKRMLNRELTHLSEMSRSGNQVSEYISNTFLDKQNDVEIPSPTQKDREKKKK
QQLMTQISGVKKLMHSSSLNNTSISRFGVNTENEDHLAKELEDLNKWGLNIFNVAGYSHN
RPLTCIMYAIFQERDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHVL
LSTPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLA
VGFKLLQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSS
GVLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEIS
PMCDKHTASVEKSQVGFIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWYQAMIPQAPA
PPLDEQNRDCQGLMEKFQFELTLDEEDSEGPEKEGEGHSYFSSTKTLCVIDPENRDSLGE
TDIDIATEDKSPVDT

BDBM285567

n/a

Name

BDBM285567

Synonyms:

3-(4-chloro-2-fluorophenyl)-N-cyclopropylimidazo[1,2-b]pyridazine-2-carboxamide | US10077269, Example 40 | US10669279, Example 40 | US9598421, Example 40

Type

Small organic molecule

Emp. Form.

C16H12ClFN4O

Mol. Mass.

330.744

SMILES

Fc1cc(Cl)ccc1-c1c(nc2cccnn12)C(=O)NC1CC1 |(-3.16,.88,;-1.67,1.28,;-1.27,2.76,;.22,3.16,;.62,4.65,;1.31,2.07,;.91,.59,;-.58,.19,;-.98,-1.3,;-.07,-2.55,;-.98,-3.79,;-2.44,-3.32,;-3.78,-4.09,;-5.11,-3.32,;-5.11,-1.78,;-3.78,-1.01,;-2.44,-1.78,;1.47,-2.55,;2.24,-1.21,;2.24,-3.88,;3.78,-3.88,;5.11,-4.65,;5.11,-3.11,)|

Structure