Reaction Details | |||
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Target | Isoform 4 of cAMP-specific 3',5'-cyclic phosphodiesterase 4A (RD1) | ||
Ligand | BDBM285628 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays | ||
IC50 | 26.6±n/a nM | ||
Citation | Chappie, TA; Patel, NC; Hayward, MM; Helal, CJ; Sciabola, S; LaChapelle, EA; Young, JM; Verhoest, PR Imidazopyridazine compounds US Patent US10077269 Publication Date 9/18/2018 | ||
More Info.: | Get all data from this article, Assay Method | ||
Isoform 4 of cAMP-specific 3',5'-cyclic phosphodiesterase 4A (RD1) | |||
Name: | Isoform 4 of cAMP-specific 3',5'-cyclic phosphodiesterase 4A (RD1) | ||
Synonyms: | DPDE2 | PDE4A | PDE4A1 | PDE4A_HUMAN | Phosphodiesterase 4A (PDE4A1) | Phosphodiesterase 4A1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4A (RD1) | cAMP-specific 3',5'-cyclic phosphodiesterase 4A Isoform 4 | ||
Type: | Enzyme Catalytic Domain | ||
Mol. Mass.: | 72186.86 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P27815-4 | ||
Residue: | 647 | ||
Sequence: |
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BDBM285628 | |||
n/a | |||
Name | BDBM285628 | ||
Synonyms: | 3-(4-cyano-5-fluoro-2-methyl-phenyl)-N-ethylimidazo[1,2-b]pyridazine-2-carboxamide | US10077269, Example 98 | US10669279, Example 98 | US9598421, Example 98 | ||
Type | Small organic molecule | ||
Emp. Form. | C17H14FN5O | ||
Mol. Mass. | 323.3244 | ||
SMILES | CCNC(=O)c1nc2cccnn2c1-c1cc(F)c(cc1C)C#N |(4.83,-5.68,;4.06,-4.34,;2.52,-4.34,;1.75,-3.01,;2.52,-1.67,;.21,-3.01,;-.7,-4.25,;-2.16,-3.78,;-3.49,-4.55,;-4.83,-3.78,;-4.83,-2.24,;-3.49,-1.47,;-2.16,-2.24,;-.7,-1.76,;-.3,-.27,;1.19,.12,;1.59,1.61,;3.08,2.01,;.49,2.8,;-.99,2.3,;-1.39,.81,;-2.87,.42,;.87,4.29,;1.25,5.78,)| | ||
Structure |