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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | ||
| Ligand | BDBM135819 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | TR-FRET-Based Phosphodiesterase Assay | ||
| IC50 | 55±n/a nM | ||
| Citation |  Mjalli, AM; Gaddam, B; Polisetti, DR; Kostura, MJ; Guzel, M Tricyclic compounds as modulators of TNF-α synthesis and as PDE4 inhibitors US Patent US8853226 Publication Date 10/7/2014 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| cAMP-specific 3',5'-cyclic phosphodiesterase 4D | |||
| Name: | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | ||
| Synonyms: | 3',5'-cyclic phosphodiesterase | DPDE3 | PDE43 | PDE4D | PDE4D_HUMAN | Phosphodiesterase 4D | ||
| Type: | Protein | ||
| Mol. Mass.: | 91092.69 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q08499 | ||
| Residue: | 809 | ||
| Sequence: |
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| BDBM135819 | |||
| n/a | |||
| Name | BDBM135819 | ||
| Synonyms: | US10085990, Example 103 | US10568888, Example 103 | US8853226, 103 | US9393245, 103 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C25H22ClN3O5 | ||
| Mol. Mass. | 479.912 | ||
| SMILES | COc1cccc2c1ncc1c2n(C2CC[C@@H](CC2)C(O)=O)c(=O)n(-c2cccc(Cl)c2)c1=O |r,wU:16.21,(-4.67,-5.78,;-3.33,-5,;-3.33,-3.47,;-4.67,-2.69,;-4.67,-1.15,;-3.33,-.38,;-2,-1.15,;-2,-2.69,;-.67,-3.47,;.67,-2.69,;.67,-1.15,;-.67,-.38,;-.67,1.15,;-2,1.93,;-2,3.47,;-3.33,4.23,;-4.67,3.47,;-4.67,1.93,;-3.33,1.15,;-6,4.23,;-7.34,3.47,;-6,5.78,;.67,1.93,;.67,3.47,;2,1.15,;3.33,1.93,;3.33,3.47,;4.67,4.23,;6,3.47,;6,1.93,;7.34,1.15,;4.67,1.15,;2,-.38,;3.33,-1.15,)| | ||
| Structure | 
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