| Reaction Details |
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 | Report a problem with these data |
| Target | Serine hydroxymethyltransferase, cytosolic |
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| Ligand | BDBM285686 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Inhibition of Human SHMT |
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| pH | 7.4±n/a |
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| IC50 | 21.0±n/a nM |
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| Comments | extracted |
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| Citation |  Rabinowitz, JD; Kim, H; Ducker, GS; Ghergurovich, JM SHMT inhibitors US Patent US10077273 Publication Date 9/18/2018 |
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| More Info.: | Get all data from this article, Assay Method |
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| Serine hydroxymethyltransferase, cytosolic |
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| Name: | Serine hydroxymethyltransferase, cytosolic |
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| Synonyms: | GLYC_HUMAN | Glycine hydroxymethyltransferase | SHMT | SHMT1 | Serine methylase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 53091.10 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_745716 |
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| Residue: | 483 |
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| Sequence: | MTMPVNGAHKDADLWSSHDKMLAQPLKDSDVEVYNIIKKESNRQRVGLELIASENFASRA
VLEALGSCLNNKYSEGYPGQRYYGGTEFIDELETLCQKRALQAYKLDPQCWGVNVQPYSG
SPANFAVYTALVEPHGRIMGLDLPDGGHLTHGFMTDKKKISATSIFFESMPYKVNPDTGY
INYDQLEENARLFHPKLIIAGTSCYSRNLEYARLRKIADENGAYLMADMAHISGLVAAGV
VPSPFEHCHVVTTTTHKTLRGCRAGMIFYRKGVKSVDPKTGKEILYNLESLINSAVFPGL
QGGPHNHAIAGVAVALKQAMTLEFKVYQHQVVANCRALSEALTELGYKIVTGGSDNHLIL
VDLRSKGTDGGRAEKVLEACSIACNKNTCPGDRSALRPSGLRLGTPALTSRGLLEKDFQK
VAHFIHRGIELTLQIQSDTGVRATLKEFKERLAGDKYQAAVQALREEVESFASLFPLPGL
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| BDBM285686 |
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| n/a |
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| Name | BDBM285686 |
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| Synonyms: | US10077273, Compound HK-16 | US10077273, Compound PK-1 | US10934305, Compound HK-16 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H16F6N4O |
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| Mol. Mass. | 430.347 |
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| SMILES | CC(C)C1(c2c(C)n[nH]c2OC(N)=C1C#N)c1cc(cc(c1)C(F)(F)F)C(F)(F)F |c:13| |
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| Structure | 
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