| Reaction Details |
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 | Report a problem with these data |
| Target | Histone deacetylase 8 |
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| Ligand | BDBM41565 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Fluor de Lys Assay |
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| Temperature | 298.15±n/a K |
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| IC50 | 22585±n/a nM |
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| Comments | extracted |
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| Citation |  Oyelere, A; Tapadar, S Non-peptide macrocyclic histone deacetylese (HDAC) inhibitors and methods of making and using thereof US Patent US8871728 Publication Date 10/28/2014 |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Histone deacetylase 8 |
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| Name: | Histone deacetylase 8 |
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| Synonyms: | HD8 | HDAC8 | HDAC8_HUMAN | HDACL1 | Histone deacetylase 8 (HDAC-8) | Human HDAC8 |
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| Type: | Enzyme |
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| Mol. Mass.: | 41749.60 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9BY41 |
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| Residue: | 377 |
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| Sequence: | MEEPEEPADSGQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPK
VASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSIEYGLGYDCPATEGIFDYAAAIGGATI
TAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLH
HGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKY
YQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLI
LGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPH
RIQQILNYIKGNLKHVV
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| BDBM41565 |
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| n/a |
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| Name | BDBM41565 |
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| Synonyms: | US8871728, 167g |
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| Type | n/a |
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| Emp. Form. | C20H18F3N5OS |
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| Mol. Mass. | 433.45 |
|---|
| SMILES | Oc1cccn(CCCCCn2cc(nn2)-c2ccc(C#N)c(c2)C(F)(F)F)c1=S |
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| Structure | 
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