| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Solute carrier family 22 member 12 |
|---|
| Ligand | BDBM139536 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Inhibition Assay |
|---|
| IC50 | 250±n/a nM |
|---|
| Citation |  O'Neil, JD; Sharma, S; Arudchandran, R Tetrazole compounds for reducing uric acid US Patent US8889724 Publication Date 11/18/2014 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Solute carrier family 22 member 12 |
|---|
| Name: | Solute carrier family 22 member 12 |
|---|
| Synonyms: | OATL4 | Organic anion transporter 4-like protein | RST | Renal-specific transporter | S22AC_HUMAN | SLC22A12 | Solute carrier family 22 member 12 | Solute carrier family 22 member 12 (URAT1) | URAT1 | Urate anion exchanger 1 | Urate anion exchanger 1 (URAT1) | Uric Acid Transporter 1 (URAT1) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 59638.65 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q96S37 |
|---|
| Residue: | 553 |
|---|
| Sequence: | MAFSELLDLVGGLGRFQVLQTMALMVSIMWLCTQSMLENFSAAVPSHRCWAPLLDNSTAQ
ASILGSLSPEALLAISIPPGPNQRPHQCRRFRQPQWQLLDPNATATSWSEADTEPCVDGW
VYDRSIFTSTIVAKWNLVCDSHALKPMAQSIYLAGILVGAAACGPASDRFGRRLVLTWSY
LQMAVMGTAAAFAPAFPVYCLFRFLLAFAVAGVMMNTGTLLMEWTAARARPLVMTLNSLG
FSFGHGLTAAVAYGVRDWTLLQLVVSVPFFLCFLYSWWLAESARWLLTTGRLDWGLQELW
RVAAINGKGAVQDTLTPEVLLSAMREELSMGQPPASLGTLLRMPGLRFRTCISTLCWFAF
GFTFFGLALDLQALGSNIFLLQMFIGVVDIPAKMGALLLLSHLGRRPTLAASLLLAGLCI
LANTLVPHEMGALRSALAVLGLGGVGAAFTCITIYSSELFPTVLRMTAVGLGQMAARGGA
ILGPLVRLLGVHGPWLPLLVYGTVPVLSGLAALLLPETQSLPLPDTIQDVQNQAVKKATH
GTLGNSVLKSTQF
|
|
|
|---|
| BDBM139536 |
|---|
| n/a |
|---|
| Name | BDBM139536 |
|---|
| Synonyms: | US8889724, ED |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C18H20N4O2 |
|---|
| Mol. Mass. | 324.377 |
|---|
| SMILES | COc1ccc(Cc2nnn[nH]2)cc1OCc1c(C)cccc1C |
|---|
| Structure | 
|
|---|
Search and Browse
