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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | 3-phosphoinositide-dependent protein kinase 1 | ||
| Ligand | BDBM139841 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Kinase Assay | ||
| pH | 7.5±n/a | ||
| IC50 | 3±n/a nM | ||
| Comments | extracted | ||
| Citation |  McConnell, D; Engelhardt, H; Kofink, C 1H-imidazo[4,5-c]quinolines US Patent US8895581 Publication Date 11/25/2014 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| 3-phosphoinositide-dependent protein kinase 1 | |||
| Name: | 3-phosphoinositide-dependent protein kinase 1 | ||
| Synonyms: | 3-Phosphoinositide-Dependent Protein Kinase 1 (PDK1) | 3-phosphoinositide dependent protein kinase-1 | 3-phosphoinositide-dependent protein kinase 1 | 3-phosphoinositide-dependent protein kinase 1 (PDK) | 3-phosphoinositide-dependent protein kinase 1 (PDK-1) | 3-phosphoinositide-dependent protein kinase 1 (PDK1)(Δ1-50) | Isoform 2 of 3-phosphoinositide-dependent protein kinase 1 | PDK1 | PDPK1 | PDPK1_HUMAN | Phosphoinositide-dependent protein kinase 1 (PDK1) | Pyruvate dehydrogenase kinase isoenzyme 1 (PDK1) | hPDK1 | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 63157.65 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | O15530 | ||
| Residue: | 556 | ||
| Sequence: |
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| BDBM139841 | |||
| n/a | |||
| Name | BDBM139841 | ||
| Synonyms: | US8895581, III-27 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C35H35FN6O3 | ||
| Mol. Mass. | 606.6892 | ||
| SMILES | CN(C)[C@H]1CC[C@H](CC1)n1cnc2cnc3ccc(cc3c12)C#CCNC(=O)c1cccn([C@@H](CO)c2cccc(F)c2)c1=O |r,wU:6.9,3.2,wD:33.36,(2.18,-2.84,;1.09,-1.75,;1.49,-.26,;-.39,-2.14,;-.79,-3.63,;-2.28,-4.03,;-3.37,-2.94,;-2.97,-1.45,;-1.48,-1.06,;-4.86,-3.34,;-5.48,-4.75,;-7.02,-4.59,;-7.34,-3.08,;-8.67,-2.31,;-8.67,-.77,;-7.34,,;-7.34,1.54,;-6,2.31,;-4.67,1.54,;-4.67,,;-6,-.77,;-6,-2.31,;-3.33,2.31,;-2,3.08,;-.67,3.85,;.67,3.08,;2,3.85,;2,5.39,;3.33,3.08,;4.67,3.85,;6,3.08,;6,1.54,;4.67,.77,;4.67,-.77,;3.33,-1.54,;3.33,-3.08,;6,-1.54,;7.34,-.77,;8.67,-1.54,;8.67,-3.08,;7.34,-3.85,;7.34,-5.39,;6,-3.08,;3.33,1.54,;2,.77,)| | ||
| Structure | 
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