| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Cytochrome P450 2B6 |
|---|
| Ligand | BDBM12345 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Inhibition Assay |
|---|
| pH | 7.5±n/a |
|---|
| IC50 | 191000±n/a nM |
|---|
| Comments | extracted |
|---|
| Citation |  Cashman, JR Synthetic compounds and methods to decrease nicotine self-administration US Patent US8906943 Publication Date 12/9/2014 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Cytochrome P450 2B6 |
|---|
| Name: | Cytochrome P450 2B6 |
|---|
| Synonyms: | CP2B6_HUMAN | CYP2B6 | Cytochrome P450 2B6 (CYP2B6) |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 56289.75 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P20813 |
|---|
| Residue: | 491 |
|---|
| Sequence: | MELSVLLFLALLTGLLLLLVQRHPNTHDRLPPGPRPLPLLGNLLQMDRRGLLKSFLRFRE
KYGDVFTVHLGPRPVVMLCGVEAIREALVDKAEAFSGRGKIAMVDPFFRGYGVIFANGNR
WKVLRRFSVTTMRDFGMGKRSVEERIQEEAQCLIEELRKSKGALMDPTFLFQSITANIIC
SIVFGKRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFELFSGFLKYFPGAHRQVYKNLQE
INAYIGHSVEKHRETLDPSAPKDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGT
ETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFS
DLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGAL
KKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFSMASPVAPEDIDLTPQECGVGKI
PPTYQIRFLPR
|
|
|
|---|
| BDBM12345 |
|---|
| n/a |
|---|
| Name | BDBM12345 |
|---|
| Synonyms: | CHEMBL178090 | US8609708, 2 | US8609708, 47 | [5-(pyridin-3-yl)furan-2-yl]methanamine | nicotine 3-heteroaromatic analogue 2a |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C10H10N2O |
|---|
| Mol. Mass. | 174.1992 |
|---|
| SMILES | NCc1ccc(o1)-c1cccnc1 |
|---|
| Structure | 
|
|---|
Search and Browse
