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TargetTyrosine-protein kinase SYK
LigandBDBM140325
Substrate/Competitorn/a
Meas. Tech.Kinase Assay
pH7.5±n/a
Temperature193.15±n/a K
IC50 0±n/a nM
Citation Hoffmann MBischoff DDahmann GKlicic JSchaenzle GWollin SLConvers-Reignier SGEast SPMarlin FJMcCarthy CScott J Substituted quinolines and their use as medicaments US Patent  US8912173 Publication Date 12/16/2014
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Tyrosine-protein kinase SYK
Name:Tyrosine-protein kinase SYK
Synonyms:Lysyl-tRNA synthetase | SYK | Spleen Tyrosine Kinase | Spleen tyrosine kinase (SYK) | Tyrosine-protein kinase SYK (Syk)
Type:Enzyme
Mol. Mass.:72079.99
Organism:Homo sapiens (Human)
Description:P43405
Residue:635
Sequence:
MASSGMADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRK
AHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPF
EDLKENLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQ
IVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQL
VEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPATWSAGGIISRIKSYSFPK
PGHRKSSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRP
KEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAE
ANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSM
GMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYA
PECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPRE
MYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN
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  Blast E-value cutoff:
BDBM140325
n/a
NameBDBM140325
Synonyms:US8912173, 51
TypeSmall organic molecule
Emp. Form.C25H27N3O3
Mol. Mass.417.5002
SMILESC[C@@H](Oc1cc(cc2ncccc12)-c1ccc(CN(C)C(C)=O)cc1)[C@H]1CNC(=O)C1 |r|
Structure
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