Reaction Details |
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Target | Steroid 17-alpha-hydroxylase/17,20 lyase |
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Ligand | BDBM140934 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Total SPA Assay |
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pH | 7.2±n/a |
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Temperature | 277.15±n/a K |
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IC50 | 2.9±n/a nM |
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Comments | extracted |
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Citation | Austin, JF; Sharma, LS; Balog, JA; Huang, A; Velaparthi, U; Darne, CP; Saulnier, MG Sulfonamide compounds useful as CYP17 inhibitors US Patent US8916553 Publication Date 12/23/2014 |
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More Info.: | Get all data from this article, Assay Method |
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Steroid 17-alpha-hydroxylase/17,20 lyase |
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Name: | Steroid 17-alpha-hydroxylase/17,20 lyase |
Synonyms: | CP17A_HUMAN | CYP17 | CYP17A1 | CYPXVII | Cytochrome P450 17A1 | Cytochrome P450 C17 (CYP17 ) | Cytochrome P450 C17 (CYP17) | Cytochrome P450 CYP17 | Cytochrome P450-C17 | Cytochrome P450-C17 (CYP17) | P450-C17 | S17AH | Steroid 17-alpha-Monooxygenase (CYP17) | Steroid 17-alpha-hydroxylase/17,20 lyase | Steroid 17-alpha-monooxygenase | cytochrome P450 monooxygenase 17 alpha hydroxylase/17,20-lyase (CYP17) |
Type: | Enzyme |
Mol. Mass.: | 57382.42 |
Organism: | Homo sapiens (Human) |
Description: | E.coli expressing human CYP17 |
Residue: | 508 |
Sequence: | MWELVALLLLTLAYLFWPKRRCPGAKYPKSLLSLPLVGSLPFLPRHGHMHNNFFKLQKKY
GPIYSVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQMATLDIASNNRKGIAFADSGAH
WQLHRRLAMATFALFKDGDQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNVIS
LICFNTSYKNGDPELNVIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRN
DLLNKILENYKEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIF
GAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREV
LRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNP
AGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVPDDGQLPSLEGIP
KVVFLIDSFKVKIKVRQAWREAQAEGST
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BDBM140934 |
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n/a |
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Name | BDBM140934 |
Synonyms: | US8916553, 143 |
Type | Small organic molecule |
Emp. Form. | C22H18N2O3S |
Mol. Mass. | 390.455 |
SMILES | COc1cc(NS(=O)(=O)c2ccccc2)ccc1-c1cncc2ccccc12 |
Structure |
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