Ki Summary

Reaction Details

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Target

Toll-like receptor 4

Ligand

BDBM633254

Substrate/Competitor

n/a

Meas. Tech.

Biological and Stability Data

EC50

1.32±n/a nM

Citation

Bazin-Lee, H; Ettenger, G; Khalaf, J; Ryter, KT Toll-like receptor ligands US Patent US11458151 Publication Date 10/4/2022

More Info.:

Get all data from this article, Assay Method

Toll-like receptor 4

Name:

Toll-like receptor 4

Synonyms:

TLR4 | TLR4-MD2 | TLR4_HUMAN

Type:

PROTEIN

Mol. Mass.:

95675.49

Organism:

Homo sapiens (Human)

Description:

ChEMBL_1436169

Residue:

839

Sequence:

MMSASRLAGTLIPAMAFLSCVRPESWEPCVEVVPNITYQCMELNFYKIPDNLPFSTKNLD
LSFNPLRHLGSYSFFSFPELQVLDLSRCEIQTIEDGAYQSLSHLSTLILTGNPIQSLALG
AFSGLSSLQKLVAVETNLASLENFPIGHLKTLKELNVAHNLIQSFKLPEYFSNLTNLEHL
DLSSNKIQSIYCTDLRVLHQMPLLNLSLDLSLNPMNFIQPGAFKEIRLHKLTLRNNFDSL
NVMKTCIQGLAGLEVHRLVLGEFRNEGNLEKFDKSALEGLCNLTIEEFRLAYLDYYLDDI
IDLFNCLTNVSSFSLVSVTIERVKDFSYNFGWQHLELVNCKFGQFPTLKLKSLKRLTFTS
NKGGNAFSEVDLPSLEFLDLSRNGLSFKGCCSQSDFGTTSLKYLDLSFNGVITMSSNFLG
LEQLEHLDFQHSNLKQMSEFSVFLSLRNLIYLDISHTHTRVAFNGIFNGLSSLEVLKMAG
NSFQENFLPDIFTELRNLTFLDLSQCQLEQLSPTAFNSLSSLQVLNMSHNNFFSLDTFPY
KCLNSLQVLDYSLNHIMTSKKQELQHFPSSLAFLNLTQNDFACTCEHQSFLQWIKDQRQL
LVEVERMECATPSDKQGMPVLSLNITCQMNKTIIGVSVLSVLVVSVVAVLVYKFYFHLML
LAGCIKYGRGENIYDAFVIYSSQDEDWVRNELVKNLEEGVPPFQLCLHYRDFIPGVAIAA
NIIHEGFHKSRKVIVVVSQHFIQSRWCIFEYEIAQTWQFLSSRAGIIFIVLQKVEKTLLR
QQVELYRLLSRNTYLEWEDSVLGRHIFWRRLRKALLDGKSWNPEGTVGTGCNWQEATSI

BDBM633254

n/a

Name

BDBM633254

Synonyms:

Preparation of N�[(R)-3-Decyloxytetradecanoyl]-O-[2,3-di-[(R)-3-decyloxytetradecanoylamino]-2,3-dideoxy-4-O-phosphono-]-β-D-allopyranosyl]-L-serine | US11458151, Compound 4 | US11458151, Compound 7

Type

Small organic molecule

Emp. Form.

C81H152N3O18P

Mol. Mass.

1487.0566

SMILES

CCCCCCCCCCC[C@H](CC(=O)N[C@@H](CO[C@@H]1OC(CO)[C@@H](OP(O)(O)=O)[C@H](NC(=O)C[C@@H](CCCCCCCCCCC)OC(=O)CCCCCCCCC)C1NC(=O)C[C@@H](CCCCCCCCCCC)OC(=O)CCCCCCCCC)C(O)=O)OC(=O)CCCCCCCCC |r|

Structure