Ki Summary

Reaction Details

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Target

Bcl-2-related protein A1

Ligand

BDBM142757

Substrate/Competitor

n/a

Meas. Tech.

Fluorescence Polarization Assay

Temperature

298.15±n/a K

IC50

700±n/a nM

Comments

extracted

Citation

Pellecchia, M; Wei, J Apogossypolone derivatives as anticancer agents US Patent US8937193 Publication Date 1/20/2015

More Info.:

Get all data from this article, Assay Method

Bcl-2-related protein A1

Name:

Bcl-2-related protein A1

Synonyms:

Type:

Apoptosis regulator protein

Mol. Mass.:

20130.01

Organism:

Homo sapiens (Human)

Description:

n/a

Residue:

175

Sequence:

MTDCEFGYIYRLAQDYLQCVLQIPQPGSGPSKTSRVLQNVAFSVQKEVEKNLKSCLDNVN
VVSVDTARTLFNQVMEKEFEDGIINWGRIVTIFAFEGILIKKLLRQQIAPDVDTYKEISY
FVAEFIMNNTGEWIRQNGGWENGFVKKFEPKSGWMTFLEVTGKICEMLSLLKQYC

BDBM142757

n/a

Name

BDBM142757

Synonyms:

US8937193, 6l

Type

Small organic molecule

Emp. Form.

C36H24Cl2O8

Mol. Mass.

655.477

SMILES

Cc1c(-c2c(C)c(=O)c3c(Cc4ccc(Cl)cc4)c(O)c(O)cc3c2=O)c(=O)c2cc(O)c(O)c(Cc3ccc(Cl)cc3)c2c1=O |(-.65,-2.45,;-1.98,-1.68,;-1.98,-.14,;-.65,.63,;-.65,2.17,;-1.98,2.94,;.69,2.94,;.69,4.48,;2.02,2.17,;3.36,2.94,;3.36,4.48,;4.69,5.25,;4.69,6.79,;6.02,7.56,;7.36,6.79,;8.69,7.56,;7.36,5.25,;6.02,4.48,;4.69,2.17,;6.02,2.94,;4.69,.63,;6.02,-.14,;3.36,-.14,;2.02,.63,;.69,-.2,;.69,-1.74,;-3.31,.68,;-3.31,2.22,;-4.65,-.14,;-5.98,.63,;-7.31,-.14,;-8.65,.63,;-7.31,-1.68,;-8.65,-2.45,;-5.98,-2.45,;-5.98,-3.99,;-7.31,-4.76,;-8.65,-3.99,;-9.98,-4.76,;-9.98,-6.3,;-11.32,-7.07,;-8.65,-7.07,;-7.31,-6.3,;-4.65,-1.68,;-3.31,-2.45,;-3.31,-3.99,)|

Structure