Ki Summary

Reaction Details

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Target

Tyrosine-protein kinase receptor

Ligand

BDBM144287

Substrate/Competitor

n/a

Meas. Tech.

Inhibition Assay

IC50

2.1±n/a nM

Citation

Shimada, I; Kurosawa, K; Matsuya, T; Iikubo, K; Kondoh, Y; Kamikawa, A; Tomiyama, H; Iwai, Y Diamino heterocyclic carboxamide compound US Patent US8969336 Publication Date 3/3/2015

More Info.:

Get all data from this article, Assay Method

Tyrosine-protein kinase receptor

Name:

Tyrosine-protein kinase receptor

Synonyms:

EML4 ALK Fusion Protein

Type:

Protein

Mol. Mass.:

87656.33

Organism:

Homo sapiens (Human)

Description:

A9YLN7

Residue:

796

Sequence:

MDGFAGSLDDSISAASTSDVQDRLSALESRVQQQEDEITVLKAALADVLRRLAISEDHVA
SVKKSVSSKGQPSPRAVIPMSCITNGSGANRKPSHTSAVSIAGKETLSSAAKSGTEKKKE
KPQGQREKKEESHSNDQSPQIRASPSPQPSSQPLQIHRQTPESKNATPTKSIKRPSPAEK
SHNSWENSDDSRNKLSKIPSTPKLIPKVTKTADKHKDVIINQAKMSTREKNSQVYRRKHQ
ELQAMQMELQSPEYKLSKLRTSTIMTDYNPNYCFAGKTSSISDLKEVPRKNITLIRGLGH
GAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIG
VSLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENH
FIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEG
IFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQ
CWQHQPEDRPNFAIILERIEYCTQDPDVINTALPIEYGPLVEEEEKVPVRPKDPEGVPPL
LVSQQAKREEERSPAAPPPLPTTSSGKAAKKPTAAEISVRVPRGPAVEGGHVNMAFSQSN
PPSELHKVHGSRNKPTSLWNPTYGSWFTEKPTKKNNPIAKKEPHDRGNLGLEGSCTVPPN
VATGRLPGASLLLEPSSLTANMKEVPLFRLRHFPCGNVNYGYQQQGLPLEAATAPGAGHY
EDTILKSKNSMNQPGP

BDBM144287

n/a

Name

BDBM144287

Synonyms:

US8969336, 343

Type

Small organic molecule

Emp. Form.

C25H37N7O2

Mol. Mass.

467.607

SMILES

CC(C)c1nc(C(N)=O)c(Nc2ccc(cc2)N2CCN(C)CC2)nc1N[C@H]1CC[C@H](O)CC1 |r,wU:30.33,wD:27.29,(4.72,1.95,;4.72,.41,;6.22,.09,;3.38,-.36,;2,.38,;.67,-.38,;-.1,.95,;.67,2.28,;-1.64,.95,;.67,-1.93,;-.67,-2.69,;-2,-1.93,;-2,-.38,;-3.33,.38,;-4.67,-.38,;-4.67,-1.93,;-3.33,-2.69,;-6,.38,;-6,1.93,;-7.34,2.69,;-8.72,1.95,;-10.05,2.72,;-8.67,.38,;-7.34,-.38,;2,-2.69,;3.33,-1.93,;4.67,-2.69,;6,-1.93,;7.34,-2.69,;8.67,-1.93,;8.67,-.38,;10,.38,;7.34,.38,;6,-.38,)|

Structure