| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Tyrosine-protein kinase receptor |
|---|
| Ligand | BDBM144316 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Inhibition Assay |
|---|
| IC50 | 2.1±n/a nM |
|---|
| Citation |  Shimada, I; Kurosawa, K; Matsuya, T; Iikubo, K; Kondoh, Y; Kamikawa, A; Tomiyama, H; Iwai, Y Diamino heterocyclic carboxamide compound US Patent US8969336 Publication Date 3/3/2015 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Tyrosine-protein kinase receptor |
|---|
| Name: | Tyrosine-protein kinase receptor |
|---|
| Synonyms: | EML4 ALK Fusion Protein |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 87656.33 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | A9YLN7 |
|---|
| Residue: | 796 |
|---|
| Sequence: | MDGFAGSLDDSISAASTSDVQDRLSALESRVQQQEDEITVLKAALADVLRRLAISEDHVA
SVKKSVSSKGQPSPRAVIPMSCITNGSGANRKPSHTSAVSIAGKETLSSAAKSGTEKKKE
KPQGQREKKEESHSNDQSPQIRASPSPQPSSQPLQIHRQTPESKNATPTKSIKRPSPAEK
SHNSWENSDDSRNKLSKIPSTPKLIPKVTKTADKHKDVIINQAKMSTREKNSQVYRRKHQ
ELQAMQMELQSPEYKLSKLRTSTIMTDYNPNYCFAGKTSSISDLKEVPRKNITLIRGLGH
GAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIG
VSLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENH
FIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEG
IFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQ
CWQHQPEDRPNFAIILERIEYCTQDPDVINTALPIEYGPLVEEEEKVPVRPKDPEGVPPL
LVSQQAKREEERSPAAPPPLPTTSSGKAAKKPTAAEISVRVPRGPAVEGGHVNMAFSQSN
PPSELHKVHGSRNKPTSLWNPTYGSWFTEKPTKKNNPIAKKEPHDRGNLGLEGSCTVPPN
VATGRLPGASLLLEPSSLTANMKEVPLFRLRHFPCGNVNYGYQQQGLPLEAATAPGAGHY
EDTILKSKNSMNQPGP
|
|
|
|---|
| BDBM144316 |
|---|
| n/a |
|---|
| Name | BDBM144316 |
|---|
| Synonyms: | US8969336, 549 | US8969336, 578 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C29H44N8O2 |
|---|
| Mol. Mass. | 536.7121 |
|---|
| SMILES | CC(C)c1nc(C(N)=O)c(Nc2ccc(cc2)N2CCC(CC2)N2CCN(C)CC2)nc1NC1CCOCC1 |
|---|
| Structure | 
|
|---|
Search and Browse
