Reaction Details | |||
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Target | Proto-oncogene tyrosine-protein kinase ROS | ||
Ligand | BDBM144324 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Inhibition Assay | ||
IC50 | 1±n/a nM | ||
Citation | Shimada, I; Kurosawa, K; Matsuya, T; Iikubo, K; Kondoh, Y; Kamikawa, A; Tomiyama, H; Iwai, Y Diamino heterocyclic carboxamide compound US Patent US8969336 Publication Date 3/3/2015 | ||
More Info.: | Get all data from this article, Assay Method | ||
Proto-oncogene tyrosine-protein kinase ROS | |||
Name: | Proto-oncogene tyrosine-protein kinase ROS | ||
Synonyms: | MCF3 | Proto-oncogene c-Ros | Proto-oncogene c-Ros-1 | ROS | ROS1 | ROS1_HUMAN | Receptor tyrosine kinase c-ros oncogene 1 | Tyrosine-Protein Kinase Receptor ROS | c-Ros receptor tyrosine kinase | ||
Type: | Enzyme | ||
Mol. Mass.: | 263897.39 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P08922 | ||
Residue: | 2347 | ||
Sequence: |
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BDBM144324 | |||
n/a | |||
Name | BDBM144324 | ||
Synonyms: | US8969336, 568 | ||
Type | Small organic molecule | ||
Emp. Form. | C30H43F3N8O2 | ||
Mol. Mass. | 604.71 | ||
SMILES | CCc1nc(C(N)=O)c(Nc2ccc(N3CCC(CC3)N3CCN(C)CC3)c(c2)C(F)(F)F)nc1N[C@H]1CC[C@H](O)CC1 |r,wU:39.43,wD:36.39,(6.59,1.24,;6.59,-.3,;5.26,-1.07,;3.88,-.33,;2.55,-1.1,;1.46,-.01,;1.85,1.48,;-.03,-.41,;2.55,-2.64,;1.21,-3.41,;-.12,-2.64,;-.12,-1.1,;-1.46,-.33,;-2.79,-1.1,;-4.12,-.33,;-5.46,-1.1,;-6.79,-.33,;-6.79,1.21,;-5.46,1.98,;-4.12,1.21,;-8.12,1.98,;-8.12,3.52,;-9.46,4.29,;-10.84,3.55,;-12.17,4.32,;-10.79,1.98,;-9.46,1.21,;-2.84,-2.67,;-1.46,-3.41,;-4.17,-3.44,;-5.5,-4.21,;-3.4,-4.77,;-4.94,-2.1,;3.88,-3.41,;5.21,-2.64,;6.55,-3.41,;7.88,-2.64,;9.21,-3.41,;10.55,-2.64,;10.55,-1.1,;11.88,-.33,;9.21,-.33,;7.88,-1.1,)| | ||
Structure |