Reaction Details | |||
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Target | Proto-oncogene tyrosine-protein kinase ROS | ||
Ligand | BDBM144325 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Inhibition Assay | ||
IC50 | 0.65±n/a nM | ||
Citation | Shimada, I; Kurosawa, K; Matsuya, T; Iikubo, K; Kondoh, Y; Kamikawa, A; Tomiyama, H; Iwai, Y Diamino heterocyclic carboxamide compound US Patent US8969336 Publication Date 3/3/2015 | ||
More Info.: | Get all data from this article, Assay Method | ||
Proto-oncogene tyrosine-protein kinase ROS | |||
Name: | Proto-oncogene tyrosine-protein kinase ROS | ||
Synonyms: | MCF3 | Proto-oncogene c-Ros | Proto-oncogene c-Ros-1 | ROS | ROS1 | ROS1_HUMAN | Receptor tyrosine kinase c-ros oncogene 1 | Tyrosine-Protein Kinase Receptor ROS | c-Ros receptor tyrosine kinase | ||
Type: | Enzyme | ||
Mol. Mass.: | 263897.39 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P08922 | ||
Residue: | 2347 | ||
Sequence: |
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BDBM144325 | |||
n/a | |||
Name | BDBM144325 | ||
Synonyms: | US8969336, 569 | ||
Type | Small organic molecule | ||
Emp. Form. | C30H46N8O2 | ||
Mol. Mass. | 550.7386 | ||
SMILES | CCc1nc(C(N)=O)c(Nc2ccc(N3CCC(CC3)N3CCN(C)CC3)c(C)c2)nc1N[C@H]1CC[C@H](O)CC1 |r,wU:33.36,wD:36.40,(6.63,1.24,;6.63,-.3,;5.29,-1.07,;3.91,-.33,;2.58,-1.1,;1.81,.24,;2.58,1.57,;.27,.24,;2.58,-2.64,;1.24,-3.41,;-.09,-2.64,;-.09,-1.1,;-1.42,-.33,;-2.76,-1.1,;-4.09,-.33,;-5.42,-1.1,;-6.76,-.33,;-6.76,1.21,;-5.42,1.98,;-4.09,1.21,;-8.09,1.98,;-8.09,3.52,;-9.43,4.29,;-10.81,3.55,;-12.14,4.32,;-10.76,1.98,;-9.43,1.21,;-2.81,-2.67,;-4.14,-3.44,;-1.42,-3.41,;3.91,-3.41,;5.24,-2.64,;6.58,-3.41,;7.91,-2.64,;7.91,-1.1,;9.25,-.33,;10.58,-1.1,;11.91,-.33,;10.58,-2.64,;9.25,-3.41,)| | ||
Structure |