| Reaction Details |
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 | Report a problem with these data |
| Target | Signal transducer and activator of transcription 3 |
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| Ligand | BDBM144581 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | EMSA Based Assay |
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| IC50 | 28000±n/a nM |
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| Citation |  Turkson, J; Hamilton, AD Inhibitors of STAT3 US Patent US8969578 Publication Date 3/3/2015 |
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| More Info.: | Get all data from this article, Assay Method |
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| Signal transducer and activator of transcription 3 |
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| Name: | Signal transducer and activator of transcription 3 |
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| Synonyms: | APRF | STAT3 | STAT3_HUMAN | Signal transducer and activator of transcription 3 | Signal transducer and activator of transcription 3 (STAT3) |
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| Type: | Protein |
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| Mol. Mass.: | 88064.31 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P40763 |
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| Residue: | 770 |
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| Sequence: | MAQWNQLQQLDTRYLEQLHQLYSDSFPMELRQFLAPWIESQDWAYAASKESHATLVFHNL
LGEIDQQYSRFLQESNVLYQHNLRRIKQFLQSRYLEKPMEIARIVARCLWEESRLLQTAA
TAAQQGGQANHPTAAVVTEKQQMLEQHLQDVRKRVQDLEQKMKVVENLQDDFDFNYKTLK
SQGDMQDLNGNNQSVTRQKMQQLEQMLTALDQMRRSIVSELAGLLSAMEYVQKTLTDEEL
ADWKRRQQIACIGGPPNICLDRLENWITSLAESQLQTRQQIKKLEELQQKVSYKGDPIVQ
HRPMLEERIVELFRNLMKSAFVVERQPCMPMHPDRPLVIKTGVQFTTKVRLLVKFPELNY
QLKIKVCIDKDSGDVAALRGSRKFNILGTNTKVMNMEESNNGSLSAEFKHLTLREQRCGN
GGRANCDASLIVTEELHLITFETEVYHQGLKIDLETHSLPVVVISNICQMPNAWASILWY
NMLTNNPKNVNFFTKPPIGTWDQVAEVLSWQFSSTTKRGLSIEQLTTLAEKLLGPGVNYS
GCQITWAKFCKENMAGKGFSFWVWLDNIIDLVKKYILALWNEGYIMGFISKERERAILST
KPPGTFLLRFSESSKEGGVTFTWVEKDISGKTQIQSVEPYTKQQLNNMSFAEIIMGYKIM
DATNILVSPLVYLYPDIPKEEAFGKYCRPESQEHPEADPGSAAPYLKTKFICVTPTTCSN
TIDLPMSPRTLDSLMQFGNNGEGAEPSAGGQFESLTFDMELTSECATSPM
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| BDBM144581 |
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| n/a |
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| Name | BDBM144581 |
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| Synonyms: | US8969578, 14 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H21N2O6PS |
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| Mol. Mass. | 496.472 |
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| SMILES | COc1ccc(NC(=O)c2nc(sc2Cc2ccc(OP(O)(O)=O)cc2)-c2ccccc2)cc1 |
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| Structure | 
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