Ki Summary

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Target

cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A

Ligand

BDBM144648

Substrate/Competitor

n/a

Meas. Tech.

IMAP TR-FRET Assay

Temperature

298.15±n/a K

IC50

15.82±n/a nM

Comments

extracted

Citation

Allen, JR; Frohn, MJ; Harrington, PE; Hu, E; Pickrell, AJ; Rzasa, RM; Sham, KK Heteroaryloxycarbocyclyl compounds as PDE10 inhibitors US Patent US8952037 Publication Date 2/10/2015

More Info.:

Get all data from this article, Assay Method

cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A

Name:

cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A

Synonyms:

Type:

Protein

Mol. Mass.:

88412.52

Organism:

Homo sapiens (Human)

Description:

Q9Y233

Residue:

1055

Sequence:

MASLEEPLAPRPQGPLPAAGDEPGCGPGKLRPEPRLSAAGGGSAAGPGPAPEWPGRGRAE
RAAPPRPPLSSAGRPSPAGGPGALSARGGGCGWVAARAPLALAFSSRVPSSSPSFFYFWP
PPPPPPPSFLPSSSAFHLPVRLPGREGAAAAAAAGGGGDAGGGGGGGQEAAPLSVPTSSS
HRGGGGSGGGRRRLFLSPALQGLLLPARAGPRPPPPPRLPLGQAARRAGSPGFPGAGPGG
GGQTPRRPQGASFALAAAAALLFGSDMEDGPSNNASCFRRLTECFLSPSLTDEKVKAYLS
LHPQVLDEFVSESVSAETVEKWLKRKNNKSEDESAPKEVSRYQDTNMQGVVYELNSYIEQ
RLDTGGDNQLLLYELSSIIKIATKADGFALYFLGECNNSLCIFTPPGIKEGKPRLIPAGP
ITQGTTVSAYVAKSRKTLLVEDILGDERFPRGTGLESGTRIQSVLCLPIVTAIGDLIGIL
ELYRHWGKEAFCLSHQEVATANLAWASVAIHQVQVCRGLAKQTELNDFLLDVSKTYFDNI
VAIDSLLEHIMIYAKNLVNADRCALFQVDHKNKELYSDLFDIGEEKEGKPVFKKTKEIRF
SIEKGIAGQVARTGEVLNIPDAYADPRFNREVDLYTGYTTRNILCMPIVSRGSVIGVVQM
VNKISGSAFSKTDENNFKMFAVFCALALHCANMYHRIRHSECIYRVTMEKLSYHSICTSE
EWQGLMQFTLPVRLCKEIELFHFDIGPFENMWPGIFVYMVHRSCGTSCFELEKLCRFIMS
VKKNYRRVPYHNWKHAVTVAHCMYAILQNNHTLFTDLERKGLLIACLCHDLDHRGFSNSY
LQKFDHPLAALYSTSTMEQHHFSQTVSILQLEGHNIFSTLSSSEYEQVLEIIRKAIIATD
LALYFGNRKQLEEMYQTGSLNLNNQSHRDRVIGLMMTACDLCSVTKLWPVTKLTANDIYA
EFWAEGDEMKKLGIQPIPMMDRDKKDEVPQGQLGFYNAVAIPCYTTLTQILPPTEPLLKA
CRDNLSQWEKVIRGEETATWISSPSVAQKAAASED

BDBM144648

n/a

Name

BDBM144648

Synonyms:

US8952037, 15

Type

Small organic molecule

Emp. Form.

C24H27N5O2

Mol. Mass.

417.5035

SMILES

CC(=O)N1CCC(CC1)c1nccnc1O[C@H]1C[C@@H](C1)Nc1ccc2ccccc2n1 |r,wU:18.22,wD:16.17,(-4.94,5,;-6.28,4.23,;-7.61,5,;-6.28,2.69,;-4.94,1.93,;-4.94,.38,;-6.28,-.38,;-7.61,.38,;-7.61,1.93,;-6.28,-1.93,;-7.61,-2.69,;-7.61,-4.23,;-6.28,-5,;-4.94,-4.23,;-4.94,-2.69,;-3.61,-1.93,;-2.28,-2.69,;-1.88,-4.18,;-.39,-3.78,;-.79,-2.3,;.94,-4.55,;2.28,-3.78,;2.28,-2.24,;3.61,-1.47,;4.94,-2.24,;6.28,-1.47,;7.61,-2.24,;7.61,-3.78,;6.28,-4.55,;4.94,-3.78,;3.61,-4.55,)|

Structure