Reaction Details |
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Target | Glutaminyl-peptide cyclotransferase |
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Ligand | BDBM149358 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Spectrophotometric Assay |
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Temperature | 303.15±n/a K |
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Ki | 6.07±n/a nM |
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IC50 | 69.7±n/a nM |
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Comments | extracted |
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Citation | Heiser, U; Sommer, R; Gaertner, U; Hamann, A; Almstetter, M; Thormann, M; Treml, A; Demuth, H; Hoffman, T Inhibitors of glutaminyl cyclase US Patent US8962860 Publication Date 2/24/2015 |
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More Info.: | Get all data from this article, Assay Method |
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Glutaminyl-peptide cyclotransferase |
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Name: | Glutaminyl-peptide cyclotransferase |
Synonyms: | Glutaminyl Cyclase | Glutaminyl cyclase (QC) | Glutaminyl-peptide cyclotransferase | Glutaminyl-peptide cyclotransferase precursor (QC) | Glutaminyl-tRNA cyclotransferase | Glutamyl cyclase (QC) | QPCT | QPCT_HUMAN |
Type: | Enzyme |
Mol. Mass.: | 40877.05 |
Organism: | Homo sapiens (Human) |
Description: | Q16769 |
Residue: | 361 |
Sequence: | MAGGRHRRVVGTLHLLLLVAALPWASRGVSPSASAWPEEKNYHQPAILNSSALRQIAEGT
SISEMWQNDLQPLLIERYPGSPGSYAARQHIMQRIQRLQADWVLEIDTFLSQTPYGYRSF
SNIISTLNPTAKRHLVLACHYDSKYFSHWNNRVFVGATDSAVPCAMMLELARALDKKLLS
LKTVSDSKPDLSLQLIFFDGEEAFLHWSPQDSLYGSRHLAAKMASTPHPPGARGTSQLHG
MDLLVLLDLIGAPNPTFPNFFPNSARWFERLQAIEHELHELGLLKDHSLEGRYFQNYSYG
GVIQDDHIPFLRRGVPVLHLIPSPFPEVWHTMDDNEENLDESTIDNLNKILQVFVLEYLH
L
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BDBM149358 |
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n/a |
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Name | BDBM149358 |
Synonyms: | US8962860, 1 |
Type | Small organic molecule |
Emp. Form. | C16H10N6O2S |
Mol. Mass. | 350.355 |
SMILES | O=C1NC(=O)N(C1c1ccc2nsnc2c1)c1ccc2[nH]cnc2c1 |
Structure |
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