| Reaction Details |
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 | Report a problem with these data |
| Target | Glutaminyl-peptide cyclotransferase |
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| Ligand | BDBM149366 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Spectrophotometric Assay |
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| Temperature | 303.15±n/a K |
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| Ki | 4.13±n/a nM |
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| IC50 | 48±n/a nM |
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| Comments | extracted |
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| Citation |  Heiser, U; Sommer, R; Gaertner, U; Hamann, A; Almstetter, M; Thormann, M; Treml, A; Demuth, H; Hoffman, T Inhibitors of glutaminyl cyclase US Patent US8962860 Publication Date 2/24/2015 |
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| More Info.: | Get all data from this article, Assay Method |
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| Glutaminyl-peptide cyclotransferase |
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| Name: | Glutaminyl-peptide cyclotransferase |
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| Synonyms: | Glutaminyl Cyclase | Glutaminyl cyclase (QC) | Glutaminyl-peptide cyclotransferase | Glutaminyl-peptide cyclotransferase precursor (QC) | Glutaminyl-tRNA cyclotransferase | Glutamyl cyclase (QC) | QPCT | QPCT_HUMAN |
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| Type: | Enzyme |
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| Mol. Mass.: | 40877.05 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q16769 |
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| Residue: | 361 |
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| Sequence: | MAGGRHRRVVGTLHLLLLVAALPWASRGVSPSASAWPEEKNYHQPAILNSSALRQIAEGT
SISEMWQNDLQPLLIERYPGSPGSYAARQHIMQRIQRLQADWVLEIDTFLSQTPYGYRSF
SNIISTLNPTAKRHLVLACHYDSKYFSHWNNRVFVGATDSAVPCAMMLELARALDKKLLS
LKTVSDSKPDLSLQLIFFDGEEAFLHWSPQDSLYGSRHLAAKMASTPHPPGARGTSQLHG
MDLLVLLDLIGAPNPTFPNFFPNSARWFERLQAIEHELHELGLLKDHSLEGRYFQNYSYG
GVIQDDHIPFLRRGVPVLHLIPSPFPEVWHTMDDNEENLDESTIDNLNKILQVFVLEYLH
L
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| BDBM149366 |
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| n/a |
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| Name | BDBM149366 |
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| Synonyms: | US8962860, 11 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H16N4O2 |
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| Mol. Mass. | 368.388 |
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| SMILES | O=C1NC(=O)N(C1c1ccc(cc1)-c1ccccc1)c1ccc2[nH]cnc2c1 |
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| Structure | 
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