| Reaction Details |
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 | Report a problem with these data |
| Target | Calcium/calmodulin-dependent protein kinase type II subunit delta |
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| Ligand | BDBM149451 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | In Vitro Inhibition Assay |
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| IC50 | 22±n/a nM |
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| Citation |  Beauverger, P; Begis, G; Biscarrat, S; Duclos, O; McCort, G 5 oxo-5,8-dihydropyrido[2,3-d]pyrimidine derivatives as CaMKII kinase inhibitors for treating cardiovascular diseases US Patent US8975250 Publication Date 3/10/2015 |
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| More Info.: | Get all data from this article, Assay Method |
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| Calcium/calmodulin-dependent protein kinase type II subunit delta |
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| Name: | Calcium/calmodulin-dependent protein kinase type II subunit delta |
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| Synonyms: | CAMK2D | CAMKD | CaM kinase II | CaM kinase II delta | CaMK-II subunit delta | Calcium/calmodulin-dependent protein kinase type II subunit delta | Calcium/calmodulin-dependent protein kinase type II subunit delta (CAMK2D) | Calcium/calmodulin-dependent protein kinase type II subunit delta (CaMKII subunit delta) | KCC2D_HUMAN |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 56419.78 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q13557 |
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| Residue: | 499 |
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| Sequence: | MASTTTCTRFTDEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLER
EARICRLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQI
LESVNHCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGY
LSPEVLRKDPYGKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDT
VTPEAKDLINKMLTINPAKRITASEALKHPWICQRSTVASMMHRQETVDCLKKFNARRKL
KGAILTTMLATRNFSAAKSLLKKPDGVKESTESSNTTIEDEDVKARKQEIIKVTEQLIEA
INNGDFEAYTKICDPGLTAFEPEALGNLVEGMDFHRFYFENALSKSNKPIHTIILNPHVH
LVGDDAACIAYIRLTQYMDGSGMPKTMQSEETRVWHRRDGKWQNVHFHRSGSPTVPIKPP
CIPNGKENFSGGTSLWQNI
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| BDBM149451 |
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| n/a |
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| Name | BDBM149451 |
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| Synonyms: | US8975250, 35 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H30F3N7O3 |
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| Mol. Mass. | 533.546 |
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| SMILES | CCn1c(N)c(C(N)=O)c(=O)c2cnc(Nc3ccc(cc3OC)C3CCN(CCC(F)(F)F)CC3)nc12 |
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| Structure | 
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